Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder - a four-year follow-up study: The Danish High Risk and Resilience Study, VIA 11

Children at familial high-risk of schizophrenia and bipolar disorder have an elevated prevalence of mental disorders but studies of children within a narrow age range are lacking and there are few conjoint studies of these two groups. Knowledge on their mental health is important for prevention and...

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Published in:Journal of child psychology and psychiatry 2022-09, Vol.63 (9), p.1046-1056
Main Authors: Gregersen, Maja, Søndergaard, Anne, Brandt, Julie Marie, Ellersgaard, Ditte, Rohd, Sinnika Birkehøj, Hjorthøj, Carsten, Ohland, Jessica, Krantz, Mette Falkenberg, Wilms, Martin, Andreassen, Anna Krogh, Knudsen, Christina Bruun, Veddum, Lotte, Greve, Aja, Bliksted, Vibeke, Mors, Ole, Clemmensen, Lars, Møllegaard Jepsen, Jens Richardt, Nordentoft, Merete, Hemager, Nicoline, Thorup, Anne Amalie Elgaard
Format: Article
Language:English
Subjects:
Adjustment disorder
Age
Anxiety disorders
Attention deficit hyperactivity disorder
Behavior disorders
Behavior Problems
Bipolar disorder
Bipolar Disorder - epidemiology
Child
Child & adolescent psychiatry
Child, Preschool
Childhood
Cohort analysis
Denmark - epidemiology
Disruptive behaviour
Early intervention
Emotional disorders
Follow-Up Studies
Humans
Longitudinal Studies
Mental disorders
Mental health
Older children
Preadolescents
Prevention programs
Preventive medicine
Schizophrenia
Schizophrenia - epidemiology
Young Children
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Summary:Children at familial high-risk of schizophrenia and bipolar disorder have an elevated prevalence of mental disorders but studies of children within a narrow age range are lacking and there are few conjoint studies of these two groups. Knowledge on their mental health is important for prevention and early intervention. The authors examined mental disorders and global functioning in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) compared with population-based controls. In a longitudinal cohort study, 450 children (FHR-SZ, n = 171; FHR-BP, n = 104; controls, n = 175), were assessed for Axis I disorders at baseline and four-year follow-up (mean age 11.9, SD 0.2) with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children and for global functioning with Children's Global Assessment Scale. Cumulative incidence of Any Axis I disorder was elevated by age 11 in children at FHR-SZ (54.4%, OR 3.0, 95% CI 1.9-4.7, p 
ISSN:0021-9630
1469-7610
DOI:10.1111/jcpp.13548