Determination of the relationship between class IV sirtuin genes and growth traits in Chinese black Tibetan sheep

Class IV sirtuin (SIRT6 and SIRT7) played essential roles in biometabolism processes via deacetylating specific transcription factors. The present study was conducted to search for mutations in SIRT6/7 and determine their associations with growth traits in black Tibetan sheep. Via DNA sequencing met...

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Bibliographic Details
Published in:Animal biotechnology 2023-11, Vol.34 (4), p.1232-1238
Main Authors: Ma, Boyan, Khan, Rajwali, Raza, Sayed Haidar Abbas, Gao, Zhanhong, Hou, Shengzhen, Ullah, Farman, Hassan, Montaser M., Hassan, Mohamed M., AlGabbani, Qwait, Alotaibi, Mashael Alhumaidi, Shah, Mujahid Ali, Gui, Linsheng
Format: Article
Language:English
Subjects:
Animal husbandry
Animals
Biomarkers
Black Tibetan sheep
Body measurements
Body weight
Body Weight - genetics
Chi-square test
combined genotype
DNA sequencing
Female
Genetic markers
Genotype
Genotype & phenotype
growth traits
Marker-assisted selection
Mutation
Nucleotides
Phenotype
Polymorphism, Single Nucleotide
Sheep
Sheep - genetics
Sheep - growth & development
Single-nucleotide polymorphism
SIRT6
SIRT7
Sirtuins - genetics
Tibet
Transcription factors
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Summary:Class IV sirtuin (SIRT6 and SIRT7) played essential roles in biometabolism processes via deacetylating specific transcription factors. The present study was conducted to search for mutations in SIRT6/7 and determine their associations with growth traits in black Tibetan sheep. Via DNA sequencing methods, three single-nucleotide polymorphisms (SNPs) were identified in 427 ewes, including a mutation (g.3724C > T) in the intron 1 of SIRT6 and two mutations (g.3668G > T and g.4223C > G) in SIRT7 intron 6 and 8, respectively. Based on the χ 2 test, both g.3724C > T and g.4223C > G loci fitted with Hardy-Weinberg equilibrium (p > 0.05). Compared with animals with genotype TT, the CC genotype at g.3724C > T locus (SIRT6) exhibited the highest mean for body weight (p 
ISSN:1049-5398
1532-2378
DOI:10.1080/10495398.2021.2016434