Predictors of persistent inflammation in children with familial Mediterranean fever

Persistent inflammation is an insidious feature of familial Mediterranean fever (FMF) that may cause chronic complications. This study aimed to investigate the predictors of persistent inflammation in children with FMF. The medical charts of 1077 paediatric FMF patients were retrospectively collecte...

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Bibliographic Details
Published in:Modern rheumatology 2022-07, Vol.32 (4), p.803-807
Main Authors: Gezgin Yıldırım, Deniz, Esmeray Senol, Pelin, Söylemezoğlu, Oğuz
Format: Article
Language:English
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Summary:Persistent inflammation is an insidious feature of familial Mediterranean fever (FMF) that may cause chronic complications. This study aimed to investigate the predictors of persistent inflammation in children with FMF. The medical charts of 1077 paediatric FMF patients were retrospectively collected. The patients were divided into two groups: with and without subclinical inflammation. A total of 133 (12%) patients had persistent inflammation. M694V homozygosity, colchicine resistance, positive family history for FMF, erysipelas-like erythema, leg pain, arthritis, chest pain, inflammatory comorbidities, early disease onset, high PRAS score, and long attack duration were established as independent predictors of persistent inflammation (P 
ISSN:1439-7595
1439-7609
DOI:10.1093/mr/roab054