Nuclear pore complexes feel the strain

A cryo-electron tomography structure of the human nuclear pore complex captured in cellulo by Schuller, Wojtynek et al. reveals that nuclear envelope tension expands the central transport channel and imposes asymmetry in the pore membrane. A cryo-electron tomography structure of the human nuclear po...

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Bibliographic Details
Published in:Molecular cell 2021-12, Vol.81 (24), p.4962-4963
Main Authors: Lusk, C. Patrick, King, Megan C.
Format: Article
Language:English
Subjects:
Humans
Nuclear Envelope
Nuclear Pore
Nuclear Pore Complex Proteins
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Summary:A cryo-electron tomography structure of the human nuclear pore complex captured in cellulo by Schuller, Wojtynek et al. reveals that nuclear envelope tension expands the central transport channel and imposes asymmetry in the pore membrane. A cryo-electron tomography structure of the human nuclear pore complex captured in cellulo by Schuller, Wojtynek et al. reveals that nuclear envelope tension expands the central transport channel and imposes asymmetry in the pore membrane.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2021.11.029