Association Between Dermcidin, Salusin-α, Salusin-β Molecules and Diabetic Foot Infections

Dermcidin, salusin-α, and salusin-β are three recently discovered molecules that confer antimicrobial properties. The present study aims to investigate the association between dermcidin, salusin-α, and salusin-β in the etiopathology of patients with diabetic foot infection. The study included three...

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Bibliographic Details
Published in:International journal of lower extremity wounds 2024-09, Vol.23 (3), p.450-454
Main Authors: Sağmak Tartar, Ayşe, Uğur, Kader, Tuncer Kara, Kevser, Akbulut, Ayhan, Demirdağ, Kutbettin, Aydin, Süleyman
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
Case-Control Studies
Dermcidins
Diabetic Foot - blood
Female
Humans
Intercellular Signaling Peptides and Proteins - blood
Male
Middle Aged
Peptides
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Summary:Dermcidin, salusin-α, and salusin-β are three recently discovered molecules that confer antimicrobial properties. The present study aims to investigate the association between dermcidin, salusin-α, and salusin-β in the etiopathology of patients with diabetic foot infection. The study included three groups: Group 1 - diabetic foot infection; Group 2 - diabetes without history of diabetic foot; and Group 3 – the control group. Plasma dermcidin, salusin-α, and salusin-β levels were compared across the groups. Median (Q1-Q3) values of plasma dermcidin levels in Groups 1, 2, and 3 were 3.45 (0.8-4.4), 5.2 (3.7-6.4), and 5.8 (3.1-10) ng/mL, respectively. Diabetic foot infection group had significantly lower plasma dermcidin levels compared to diabetes only group and control group (P = .000, ANOVA), whereas there was no statistically significant difference between the Group 2 and Group 3 (P = .163, ANOVA). Salusin-α and salusin-β levels were significantly higher in the Group 3 compared to the other groups. Based on our findings, diabetic foot infection group had significantly lower plasma dermcidin levels and salusin-α and salusin-β levels were significantly higher in the control group. These molecules (dermcidin specifically) can be researched as an adjuvant therapeutic agent in addition to conventional treatments in diabetic foot diabetic foot infections. Also, it can be searched this may prevent many complications including amputation.
ISSN:1534-7346
1552-6941
1552-6941
DOI:10.1177/15347346211065527