Underestimation of impaired glucose tolerance and usefulness of a continuous glucose monitoring system in chronic liver disease

Background and Aim The prevalence of glucose intolerance in chronic liver disease patients is high, but glucose intolerance may be overlooked in a single blood test. The purpose of this study is to evaluate blood glucose variability in patients with chronic liver disease by a continuous glucose moni...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2022-03, Vol.37 (3), p.592-599
Main Authors: Ogawa, Yutaro, Nakahara, Takashi, Ono, Masafumi, Kawaguchi, Takumi, Isoda, Hiroshi, Hiramatsu, Akira, Uchikawa, Shinsuke, Fujino, Hatsue, Murakami, Eisuke, Kawaoka, Tomokazu, Yamauchi, Masami, Tsuge, Masataka, Munekage, Kensuke, Ochi, Tsunehiro, Hayes, C Nelson, Imamura, Michio, Aikata, Hiroshi, Takahashi, Hirokazu, Torimura, Takuji, Chayama, Kazuaki
Format: Article
Language:English
Subjects:
Blood glucose
Blood tests
Body mass index
Chromium
Chronic Disease
Continuous glucose monitoring system (CGMS)
Glucose
Glucose Intolerance - diagnosis
Glucose Intolerance - epidemiology
Glucose monitoring
Glucose tolerance
Glycated Hemoglobin A - analysis
HbA1c
Hemoglobin
Humans
Hyperglycemia
Hypoglycemia
Insulin
Insulin resistance
Intolerance
Liver cirrhosis
Liver cirrhosis (LC)
Liver diseases
Liver Diseases - blood
Monitoring systems
Monitoring, Physiologic
Multiple regression analysis
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Summary:Background and Aim The prevalence of glucose intolerance in chronic liver disease patients is high, but glucose intolerance may be overlooked in a single blood test. The purpose of this study is to evaluate blood glucose variability in patients with chronic liver disease by a continuous glucose monitoring system (CGMS) and to examine the discrepancy between hemoglobin A1c (HbA1c) levels estimated from average blood glucose levels and HbA1c. Methods This study included 335 patients with chronic liver disease associated with glucose intolerance. A fasting blood test and 72‐h CGMS were performed. The estimated HbA1c was calculated from the average blood glucose level, and the correlation between hepatic functional reserve and blood glucose‐related parameters was analyzed. From the obtained data, we created a new formula to calculate HbA1c without using CGMS. Results As hepatic functional reserve decreased, average blood glucose and insulin resistance increased while HbA1c decreased (P 
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.15766