Valsartan- and melatonin-supported adipose-derived mesenchymal stem cells preserve renal function in chronic kidney disease rat through upregulation of prion protein participated in promoting PI3K-Akt-mTOR signaling and cell proliferation

This study tested the hypothesis that valsartan (Val) and melatonin (Mel)-assisted adipose-derived mesenchymal stem cells (ADMSCs) preserved the residual renal function in chronic kidney disease (CKD) rat through promoting cellular-prior-protein (PrPC) to upregulate PI3K/Akt/mTOR signaling and cell...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2022-02, Vol.146, p.112551-112551, Article 112551
Main Authors: Yang, Chih-Chao, Sung, Pei-Hsun, Chen, Kuan-Hung, Chai, Han-Tan, Chiang, John Y., Ko, Sheung-Fat, Lee, Fan-Yen, Yip, Hon-Kan
Format: Article
Language:English
Subjects:
Adipose-derived mesenchymal stem cells
Cellular prior protein
Melatonin
Oxidative stress
Valsartan
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Summary:This study tested the hypothesis that valsartan (Val) and melatonin (Mel)-assisted adipose-derived mesenchymal stem cells (ADMSCs) preserved the residual renal function in chronic kidney disease (CKD) rat through promoting cellular-prior-protein (PrPC) to upregulate PI3K/Akt/mTOR signaling and cell proliferation. In vitro study demonstrated that as compared with CKD-derived-ADMSCs, Val/Mel/overexpression of PrPC-treated CKD derived-ADMSCs significantly upregulated cell proliferation and protein expressions of PrPC and phosphorylated (p)-PI3K/p-Akt/p-mTOR, and downregulated oxidative stress (all p 
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2021.112551