Micro-RNA levels and symptom profile after mild traumatic brain injury: A longitudinal cohort study

•Patients with mTBI had higher levels of micro-RNA than healthy controls.•At day 7, pattern of change in micro-RNA levels were similar to symptom severity.•At day 28, pattern of change in micro-RNA levels were different to symptom severity.•Micro-RNA levels among recovered patients were different to...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical neuroscience 2022-01, Vol.95, p.81-87
Main Authors: Mitra, Biswadev, Reyes, Jonathan, O'Brien, William T., Surendran, Nanda, Carter, Annie, Bain, Jesse, McEntaggart, Laura, Sorich, Edmond, Shultz, Sandy R., O'Brien, Terence J., Willmott, Catherine, Rosenfeld, Jeffrey V., McDonald, Stuart J.
Format: Article
Language:English
Subjects:
Biomarkers
Brain Concussion - diagnosis
Craniocerebral Trauma
Emergency medicine
Humans
Longitudinal Studies
MicroRNAs
Post-Concussion Syndrome
Prospective Studies
Sports
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Patients with mTBI had higher levels of micro-RNA than healthy controls.•At day 7, pattern of change in micro-RNA levels were similar to symptom severity.•At day 28, pattern of change in micro-RNA levels were different to symptom severity.•Micro-RNA levels among recovered patients were different to those reporting symptoms.•Micro-RNA levels may provide unique information on brain injury and healing. Micro riboneucleic acids (miRNAs) may be transcribed after brain injury and be detectable in plasma. This study aimed to assess the discriminative ability of seven miRNAs in plasma to differentiate between patients with mild traumatic brain injury (mTBI) and healthy controls. Changes in miRNA levels over 28 days were compared to changes in self-reported symptom profile. This was a prospective cohort study with longitudinal measurements of miRNA levels and symptom self-report. The Rivermead Post-Concussion Symptom Questionnaire (RPQ) was used to determine symptom severity. Mean normalised expression ratios (NER) of miRNAs at day 0 between mTBI and healthy controls were compared. An analysis of response profiles compared the response over time of miRNA species with RPQ symptom severity. miRNA levels of subjects who were defined to have “recovered” on Day 7 and 28 were compared to “non-recovered” subjects. There were 28 mTBI patients and 30 healthy controls included for analysis. Symptom severity was significantly higher on the day of injury among mTBI subjects (p 
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2021.11.021