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Severity of Bronchopulmonary Dysplasia and Neurodevelopmental Outcome at 2 and 5 Years Corrected Age
To evaluate the association between bronchopulmonary dysplasia (BPD) severity and risk of neurodevelopmental impairment (NDI) at 2 years and 5 years corrected age and to examine whether this association changes over time. This single-center retrospective cohort study included patients with a gestati...
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| Published in: | The Journal of pediatrics 2022-04, Vol.243, p.40-46.e2 |
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| container_end_page | 46.e2 |
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| container_title | The Journal of pediatrics |
| container_volume | 243 |
| creator | Katz, Trixie A. Vliegenthart, Roseanne J.S. Aarnoudse-Moens, Cornelieke S.H. Leemhuis, Aleid G. Beuger, Sabine Blok, Geert Jan van Brakel, Monique J.M. van den Heuvel, Maria E.N. van Kempen, Anne A.M.W. Lutterman, Claire Rijpert, Maarten Schiering, Irene A. Ran, Nicolien C. Visser, Fenna Wilms, Janneke van Kaam, Anton H. Onland, Wes |
| description | To evaluate the association between bronchopulmonary dysplasia (BPD) severity and risk of neurodevelopmental impairment (NDI) at 2 years and 5 years corrected age and to examine whether this association changes over time.
This single-center retrospective cohort study included patients with a gestational age |
| doi_str_mv | 10.1016/j.jpeds.2021.12.018 |
| format | article |
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This single-center retrospective cohort study included patients with a gestational age <30 weeks surviving to 36 weeks postmenstrual age, divided into groups according to BPD severity. NDI was defined as having cognitive or motor abilities below −1 SD, cerebral palsy, or a hearing or a visual impairment. The association was assessed using a multivariate logistic regression model analysis, adjusting for known confounders for NDI, and mixed-model analysis.
Of the 790 surviving infants (15% diagnosed with mild BPD, 9% with moderate BPD, and 10% with severe BPD), 88% and 82% were longitudinally assessed at 2 years and 5 years corrected age, respectively. The mixed-model analysis showed a statistically significant increase in NDI at all levels of BPD severity compared with infants with no BPD, and a 5-fold increased risk in NDI was seen from 2 years to 5 years corrected age in all degrees of BPD severity. The strength of this association between NDI and BPD severity did not change over time.
Increased BPD severity is associated with increased risk of NDI at both 2 years and 5 years corrected age. The absolute incidence of NDI increased significantly from 2 years to 5 years corrected age for all BPD severity categories, but this increased risk was similar at both time points in each category.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2021.12.018</identifier><identifier>PMID: 34929243</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bronchopulmonary Dysplasia - complications ; Bronchopulmonary Dysplasia - diagnosis ; Bronchopulmonary Dysplasia - epidemiology ; Cerebral Palsy - epidemiology ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Retrospective Studies</subject><ispartof>The Journal of pediatrics, 2022-04, Vol.243, p.40-46.e2</ispartof><rights>2021 The Author(s)</rights><rights>Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-3f6158604175080805902971d754667d4132198a414674f7c18be1d97143b9e93</citedby><cites>FETCH-LOGICAL-c404t-3f6158604175080805902971d754667d4132198a414674f7c18be1d97143b9e93</cites><orcidid>0000-0002-4414-9451 ; 0000-0003-3959-7353 ; 0000-0002-9623-0606</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34929243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katz, Trixie A.</creatorcontrib><creatorcontrib>Vliegenthart, Roseanne J.S.</creatorcontrib><creatorcontrib>Aarnoudse-Moens, Cornelieke S.H.</creatorcontrib><creatorcontrib>Leemhuis, Aleid G.</creatorcontrib><creatorcontrib>Beuger, Sabine</creatorcontrib><creatorcontrib>Blok, Geert Jan</creatorcontrib><creatorcontrib>van Brakel, Monique J.M.</creatorcontrib><creatorcontrib>van den Heuvel, Maria E.N.</creatorcontrib><creatorcontrib>van Kempen, Anne A.M.W.</creatorcontrib><creatorcontrib>Lutterman, Claire</creatorcontrib><creatorcontrib>Rijpert, Maarten</creatorcontrib><creatorcontrib>Schiering, Irene A.</creatorcontrib><creatorcontrib>Ran, Nicolien C.</creatorcontrib><creatorcontrib>Visser, Fenna</creatorcontrib><creatorcontrib>Wilms, Janneke</creatorcontrib><creatorcontrib>van Kaam, Anton H.</creatorcontrib><creatorcontrib>Onland, Wes</creatorcontrib><title>Severity of Bronchopulmonary Dysplasia and Neurodevelopmental Outcome at 2 and 5 Years Corrected Age</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>To evaluate the association between bronchopulmonary dysplasia (BPD) severity and risk of neurodevelopmental impairment (NDI) at 2 years and 5 years corrected age and to examine whether this association changes over time.
This single-center retrospective cohort study included patients with a gestational age <30 weeks surviving to 36 weeks postmenstrual age, divided into groups according to BPD severity. NDI was defined as having cognitive or motor abilities below −1 SD, cerebral palsy, or a hearing or a visual impairment. The association was assessed using a multivariate logistic regression model analysis, adjusting for known confounders for NDI, and mixed-model analysis.
Of the 790 surviving infants (15% diagnosed with mild BPD, 9% with moderate BPD, and 10% with severe BPD), 88% and 82% were longitudinally assessed at 2 years and 5 years corrected age, respectively. The mixed-model analysis showed a statistically significant increase in NDI at all levels of BPD severity compared with infants with no BPD, and a 5-fold increased risk in NDI was seen from 2 years to 5 years corrected age in all degrees of BPD severity. The strength of this association between NDI and BPD severity did not change over time.
Increased BPD severity is associated with increased risk of NDI at both 2 years and 5 years corrected age. The absolute incidence of NDI increased significantly from 2 years to 5 years corrected age for all BPD severity categories, but this increased risk was similar at both time points in each category.</description><subject>Bronchopulmonary Dysplasia - complications</subject><subject>Bronchopulmonary Dysplasia - diagnosis</subject><subject>Bronchopulmonary Dysplasia - epidemiology</subject><subject>Cerebral Palsy - epidemiology</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Retrospective Studies</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kM9u1DAQhy0EotvCEyAhH7kkzNjOHx84lC0FpIoegAMny2tPIKskDnZSad-GZ-HJ8HYLRzSHuXy_-Wk-xl4glAhYv96X-5l8KgUILFGUgO0jtkHQTVG3Uj5mGwAhCqma-oydp7QHAK0AnrIzqbTQQskNo890R7FfDjx0_G0Mk_sR5nUYw2TjgV8d0jzY1FtuJ88_0RqDz_wQ5pGmxQ78dl1cGInbhYt7pvr96xvZmPg2xEhuIc8vv9Mz9qSzQ6LnD_uCfb1-92X7obi5ff9xe3lTOAVqKWRXY9XWoLCpoM1TaRC6Qd9Uqq4br1AK1K1VqOpGdY3DdkfoM6HkTpOWF-zV6e4cw8-V0mLGPjkaBjtRWJMRNQrZKtBVRuUJdTGkFKkzc-zH_LRBMEe_Zm_u_ZqjX4PCZL859fKhYN2N5P9l_grNwJsTQPnNu56iSa6nyZHvjzqMD_1_C_4A4HSLtw</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Katz, Trixie A.</creator><creator>Vliegenthart, Roseanne J.S.</creator><creator>Aarnoudse-Moens, Cornelieke S.H.</creator><creator>Leemhuis, Aleid G.</creator><creator>Beuger, Sabine</creator><creator>Blok, Geert Jan</creator><creator>van Brakel, Monique J.M.</creator><creator>van den Heuvel, Maria E.N.</creator><creator>van Kempen, Anne A.M.W.</creator><creator>Lutterman, Claire</creator><creator>Rijpert, Maarten</creator><creator>Schiering, Irene A.</creator><creator>Ran, Nicolien C.</creator><creator>Visser, Fenna</creator><creator>Wilms, Janneke</creator><creator>van Kaam, Anton H.</creator><creator>Onland, Wes</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4414-9451</orcidid><orcidid>https://orcid.org/0000-0003-3959-7353</orcidid><orcidid>https://orcid.org/0000-0002-9623-0606</orcidid></search><sort><creationdate>202204</creationdate><title>Severity of Bronchopulmonary Dysplasia and Neurodevelopmental Outcome at 2 and 5 Years Corrected Age</title><author>Katz, Trixie A. ; Vliegenthart, Roseanne J.S. ; Aarnoudse-Moens, Cornelieke S.H. ; Leemhuis, Aleid G. ; Beuger, Sabine ; Blok, Geert Jan ; van Brakel, Monique J.M. ; van den Heuvel, Maria E.N. ; van Kempen, Anne A.M.W. ; Lutterman, Claire ; Rijpert, Maarten ; Schiering, Irene A. ; Ran, Nicolien C. ; Visser, Fenna ; Wilms, Janneke ; van Kaam, Anton H. ; Onland, Wes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-3f6158604175080805902971d754667d4132198a414674f7c18be1d97143b9e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bronchopulmonary Dysplasia - complications</topic><topic>Bronchopulmonary Dysplasia - diagnosis</topic><topic>Bronchopulmonary Dysplasia - epidemiology</topic><topic>Cerebral Palsy - epidemiology</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katz, Trixie A.</creatorcontrib><creatorcontrib>Vliegenthart, Roseanne J.S.</creatorcontrib><creatorcontrib>Aarnoudse-Moens, Cornelieke S.H.</creatorcontrib><creatorcontrib>Leemhuis, Aleid G.</creatorcontrib><creatorcontrib>Beuger, Sabine</creatorcontrib><creatorcontrib>Blok, Geert Jan</creatorcontrib><creatorcontrib>van Brakel, Monique J.M.</creatorcontrib><creatorcontrib>van den Heuvel, Maria E.N.</creatorcontrib><creatorcontrib>van Kempen, Anne A.M.W.</creatorcontrib><creatorcontrib>Lutterman, Claire</creatorcontrib><creatorcontrib>Rijpert, Maarten</creatorcontrib><creatorcontrib>Schiering, Irene A.</creatorcontrib><creatorcontrib>Ran, Nicolien C.</creatorcontrib><creatorcontrib>Visser, Fenna</creatorcontrib><creatorcontrib>Wilms, Janneke</creatorcontrib><creatorcontrib>van Kaam, Anton H.</creatorcontrib><creatorcontrib>Onland, Wes</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katz, Trixie A.</au><au>Vliegenthart, Roseanne J.S.</au><au>Aarnoudse-Moens, Cornelieke S.H.</au><au>Leemhuis, Aleid G.</au><au>Beuger, Sabine</au><au>Blok, Geert Jan</au><au>van Brakel, Monique J.M.</au><au>van den Heuvel, Maria E.N.</au><au>van Kempen, Anne A.M.W.</au><au>Lutterman, Claire</au><au>Rijpert, Maarten</au><au>Schiering, Irene A.</au><au>Ran, Nicolien C.</au><au>Visser, Fenna</au><au>Wilms, Janneke</au><au>van Kaam, Anton H.</au><au>Onland, Wes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severity of Bronchopulmonary Dysplasia and Neurodevelopmental Outcome at 2 and 5 Years Corrected Age</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2022-04</date><risdate>2022</risdate><volume>243</volume><spage>40</spage><epage>46.e2</epage><pages>40-46.e2</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>To evaluate the association between bronchopulmonary dysplasia (BPD) severity and risk of neurodevelopmental impairment (NDI) at 2 years and 5 years corrected age and to examine whether this association changes over time.
This single-center retrospective cohort study included patients with a gestational age <30 weeks surviving to 36 weeks postmenstrual age, divided into groups according to BPD severity. NDI was defined as having cognitive or motor abilities below −1 SD, cerebral palsy, or a hearing or a visual impairment. The association was assessed using a multivariate logistic regression model analysis, adjusting for known confounders for NDI, and mixed-model analysis.
Of the 790 surviving infants (15% diagnosed with mild BPD, 9% with moderate BPD, and 10% with severe BPD), 88% and 82% were longitudinally assessed at 2 years and 5 years corrected age, respectively. The mixed-model analysis showed a statistically significant increase in NDI at all levels of BPD severity compared with infants with no BPD, and a 5-fold increased risk in NDI was seen from 2 years to 5 years corrected age in all degrees of BPD severity. The strength of this association between NDI and BPD severity did not change over time.
Increased BPD severity is associated with increased risk of NDI at both 2 years and 5 years corrected age. The absolute incidence of NDI increased significantly from 2 years to 5 years corrected age for all BPD severity categories, but this increased risk was similar at both time points in each category.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34929243</pmid><doi>10.1016/j.jpeds.2021.12.018</doi><orcidid>https://orcid.org/0000-0002-4414-9451</orcidid><orcidid>https://orcid.org/0000-0003-3959-7353</orcidid><orcidid>https://orcid.org/0000-0002-9623-0606</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Elsevier |
| subjects | Bronchopulmonary Dysplasia - complications Bronchopulmonary Dysplasia - diagnosis Bronchopulmonary Dysplasia - epidemiology Cerebral Palsy - epidemiology Gestational Age Humans Infant Infant, Newborn Infant, Premature Retrospective Studies |
| title | Severity of Bronchopulmonary Dysplasia and Neurodevelopmental Outcome at 2 and 5 Years Corrected Age |
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