Relationship between immunometabolic status and cognitive performance among major depression disorder patients

• Published in: Psychoneuroendocrinology 2022-03, Vol.137, p.105631-105631, Article 105631
• Main Authors: Sánchez-Carro, Yolanda, de la Torre-Luque, Alejandro, Portella, Maria J., Leal-Leturia, Itziar, Salvat-Pujol, Neus, Massaneda, Clara, de Arriba-Arnau, Aida, Urretavizcaya, Mikel, Peretó, Mar, Toll, Alba, Martínez-Ruiz, Antonio, Ferreiros-Martinez, Raquel, Álvarez, Pilar, Soria, Virginia, López-García, Pilar
• Format: Article
• Language: English
• Subjects: Cognition; Cognitive Dysfunction - complications; Cognitive performance; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Humans; Inflammation, Oxidative stress; Major depressive disorder; Metabolic Syndrome
• ISSN: 0306-4530; 1873-3360
• DOI: 10.1016/j.psyneuen.2021.105631

Alterations in cognitive performance have been described in patients with major depressive disorder (MDD). However, the specific risk factors of these changes are not yet known. This study aimed to explore whether inmunometabolic parameters are related to cognitive performance in MDD in comparison to healthy controls (HC) Sample consisted of 84 MDD patients and 78 HC. Both groups were compared on the results of cognitive performance measured with the Cambridge Neuropsychological Test Automated Battery (CANTAB), the presence of metabolic syndrome (MetS) and an inflammatory/oxidative index calculated by a principal component analysis of peripheral biomarkers (tumor necrosis factor, C-reactive protein and 4-hydroxynonenal). A multiple linear regression was carried out, to study the relationship between inmunometabolic variables and the global cognitive performance, being the latter the dependent variable. Significant differences were obtained in the inflammatory/oxidative index between both groups (F(1157)= 12.93; p