Impact of adaptive gastric electrical stimulation on weight, food intake, and food intake rate in dogs

Background Gastric electrical stimulation (GES) has been studied for decades as a promising treatment for obesity. Stimulation pulses with fixed amplitude and pulse width are usually applied, but these have limitations with regard to overcoming habituation to GES and inter‐subject variation. This st...

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Bibliographic Details
Published in:Artificial organs 2022-06, Vol.46 (6), p.1055-1067
Main Authors: Debelle, Adrien, Hesta, Myriam, Rooster, Hilde, Bianchini, Erika, Vanhoestenberghe, Anne, Stock, Emmelie, Vanderperren, Katrien, Polis, Ingeborgh, Smets, Hugo, Cury, Joaquin, Acuña, Vicente, Delchambre, Alain, Innocenti, Bernardo, Devière, Jacques, Nonclercq, Antoine
Format: Article
Language:English
Subjects:
adaptive stimulation
Body weight
Dogs
Electrical stimuli
Energy requirements
Food
Food consumption
Food intake
gastric electrical stimulation
Habituation
Habituation (learning)
Maintenance
Obesity
Pulse duration
Stimulation
Stimulators
weight loss
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Summary:Background Gastric electrical stimulation (GES) has been studied for decades as a promising treatment for obesity. Stimulation pulses with fixed amplitude and pulse width are usually applied, but these have limitations with regard to overcoming habituation to GES and inter‐subject variation. This study aims to analyze the efficacy of an adaptive GES protocol for reducing food intake and maintaining lean weight in dogs. Methods Six beagle dogs were implanted with a remotely programmable gastric stimulator. An adaptive protocol was designed to increase the stimulation energy proportionally to the excess of food consumption, with respect to the dogs’ maintenance energy requirements. After surgery and habituation to experimental conditions, the dogs went through both a control and a stimulation period of 4 weeks each, in a randomized order. The stimulation parameters were adapted daily. Body weight, food intake, food intake rate, and postprandial cutaneous electrogastrograms (EGG) were recorded to assess the effect of adaptive GES. Results Adaptive GES decreased food intake and food intake rate (p 
ISSN:0160-564X
1525-1594
DOI:10.1111/aor.14156