Cembranoids from the Vietnamese soft coral Sarcophyton ehrenbergi

Using various chromatographic separations, two new cembranoids, ehrenbergols F and G (1 and 2), along with three known analogs ehrenbergol D (3), (+)-isosarcophine (4) and sinulariol Z 2 (5) were isolated from the soft coral Sarcophyton ehrenbergi. The structural elucidation was done by extensive an...

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Bibliographic Details
Published in:Natural product research 2022-11, Vol.36 (21), p.5517-5523
Main Authors: Ninh Thi, Ngoc, Tran Thi Hong, Hanh, Tran Hong, Quang, Nguyen Xuan, Cuong, Nguyen Hoai, Nam, Thi Thao, Do, Cuong, Pham Van, Do Cong, Thung, Phan Van, Kiem, Van Minh, Chau
Format: Article
Language:English
Subjects:
Alcyoniidae
cembranoid
Lipopolysaccharides
NMR
NO production
Nuclear magnetic resonance
Sarcophyton ehrenbergi
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Summary:Using various chromatographic separations, two new cembranoids, ehrenbergols F and G (1 and 2), along with three known analogs ehrenbergol D (3), (+)-isosarcophine (4) and sinulariol Z 2 (5) were isolated from the soft coral Sarcophyton ehrenbergi. The structural elucidation was done by extensive analysis of the 1 D and 2 D NMR, HR-ESI-QTOF-MS as well as CD experiments. In addition, compounds 1 (IC 50 of 38.38 ± 2.89 µM), 3 (IC 50 of 37.14 ± 3.22 µM) and 4 (IC 50 of 45.01 ± 2.49 µM) revealed moderate inhibitory activity on LPS-induced NO production in RAW264.7 cells, whereas 2 (IC 50 of 73.32 ± 1.95 µM) and 5 (IC 50 of 64.48 ± 4.93 µM) exhibited weak effect.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.2018587