Consensus guidelines for the diagnosis and management of cryptococcosis and rare yeast infections in the haematology/oncology setting, 2021

Cryptococcosis caused by the Cryptococcus neoformans–Cryptococcus gattii complex is an important opportunistic infection in people with immunodeficiency, including in the haematology/oncology setting. This may manifest clinically as cryptococcal meningitis or pulmonary cryptococcosis, or be detected...

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Bibliographic Details
Published in:Internal medicine journal 2021-11, Vol.51 (S7), p.118-142
Main Authors: Chang, Christina C., Hall, Victoria, Cooper, Celia, Grigoriadis, George, Beardsley, Justin, Sorrell, Tania C., Heath, Christopher H.
Format: Article
Language:English
Subjects:
Antigenemia
Australia - epidemiology
C. gattii
cryptococcal meningitis
Cryptococcosis
Cryptococcosis - diagnosis
Cryptococcosis - drug therapy
Cryptococcus gattii
Cryptococcus neoformans
Cryptococcus spp
Fungal infections
Hematology
Humans
immune reconstitution inflammatory syndrome
Immunodeficiency
Meningitis
Oncology
Opportunist infection
Saccharomyces cerevisiae
Sputum
Yeast
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Summary:Cryptococcosis caused by the Cryptococcus neoformans–Cryptococcus gattii complex is an important opportunistic infection in people with immunodeficiency, including in the haematology/oncology setting. This may manifest clinically as cryptococcal meningitis or pulmonary cryptococcosis, or be detected incidentally by cryptococcal antigenemia, a positive sputum culture or radiological imaging. Non‐Candida, non‐Cryptococcus spp. rare yeast fungaemia are increasingly common in this population. These consensus guidelines aim to provide clinicians working in the Australian and New Zealand haematology/oncology setting with clear guiding principles and practical recommendations for the management of cryptococcosis, while also highlighting important and emerging rare yeast infections and their recommended management.
ISSN:1444-0903
1445-5994
DOI:10.1111/imj.15590