Intracellular Enzyme-Responsive Profluorophore and Prodrug Nanoparticles for Tumor-Specific Imaging and Precise Chemotherapy

Responsive drug delivery systems possess great potential in disease diagnosis and treatment. Herein, we develop an activatable prodrug and fluorescence imaging material by engineering the endogenous NAD­(P)­H:quinone oxidoreductase-1 (NQO1) responsive linker. The as-prepared nanomaterials possess th...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2021-12, Vol.13 (50), p.59708-59719
Main Authors: Pei, Qing, Lu, Shaojin, Zhou, Junli, Jiang, Bowen, Li, Chaonan, Xie, Zhigang, Jing, Xiabin
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Biological and Medical Applications of Materials and Interfaces
Cell Line
Cell Survival - drug effects
Drug Delivery Systems
Drug Liberation
Drug Screening Assays, Antitumor
Humans
Materials Testing
Mice
Molecular Structure
NAD(P)H Dehydrogenase (Quinone) - metabolism
Nanoparticles - chemistry
Neoplasms - diagnostic imaging
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms, Experimental - diagnostic imaging
Neoplasms, Experimental - drug therapy
Neoplasms, Experimental - metabolism
Optical Imaging
Particle Size
Precision Medicine
Prodrugs - chemical synthesis
Prodrugs - chemistry
Prodrugs - pharmacology
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Summary:Responsive drug delivery systems possess great potential in disease diagnosis and treatment. Herein, we develop an activatable prodrug and fluorescence imaging material by engineering the endogenous NAD­(P)­H:quinone oxidoreductase-1 (NQO1) responsive linker. The as-prepared nanomaterials possess the NQO1-switched drug release and fluorescence enablement, which realizes the tumor-specific chemotherapy and imaging in living mice. The enzyme-sensitive prodrug nanoparticles exhibit selectively potent anticancer performance to NQO1-positive cancer and ignorable off-target toxicity. This work provides an alternative strategy for constructing smart prodrug nanoplatforms with precision, selectivity, and practicability for advanced cancer imaging and therapy.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.1c19058