The synthesis of aryl-heteroaryl derivatives via the RhIII-catalyzed heteroarylation of arenes and heteroaromatic boronates

An efficient RhIII-catalyzed strategy for constructing aryl-heteroaryl derivatives with removable ketoxime ether auxiliaries via direct C–H heteroarylation based on arenes and heteroaromatic boronates has been disclosed. This protocol could tolerate various pyridine, pyrimidine, pyrazole, thiophene,...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2022-01, Vol.20 (3), p.686-693
Main Authors: Wang, Huai-Wei, Jia-Xue, Wu, Da-Cheng, Li, Yu-Han, Qiao, Qing-Xia, Yao, Wen-Can, Sun, Jian-Min Dou
Format: Article
Language:English
Subjects:
Aromatic compounds
Chemical synthesis
Pyrazole
Pyrazoles
Regioselectivity
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Summary:An efficient RhIII-catalyzed strategy for constructing aryl-heteroaryl derivatives with removable ketoxime ether auxiliaries via direct C–H heteroarylation based on arenes and heteroaromatic boronates has been disclosed. This protocol could tolerate various pyridine, pyrimidine, pyrazole, thiophene, and furan heteroaromatic boronates well, providing the desired products with high reactivities and excellent regioselectivity. The easy synthetic accessibility may offer potential for application in the synthesis of heterocyclic drug molecules containing aryl-heteroaryl motifs.
ISSN:1477-0520
1477-0539
DOI:10.1039/d1ob02201f