The role of Intestinal-Fatty Acid Binding Proteins and Chitinase-3-Like Protein 1 across the spectrum of dysglycemia

• Published in: Diabetes & metabolic syndrome clinical research & reviews 2022-01, Vol.16 (1), p.102366-102366, Article 102366
• Main Authors: Sianipar, Imelda R., Sestramita, Sestramita, Pradnjaparamita, Tika, Yunir, Em, Harbuwono, Dante S., Soewondo, Pradana, Tahapary, Dicky L.
• Format: Article
• Language: English
• Subjects: Biomarkers; Chitinase-3-Like Protein 1 - metabolism; Chitinases; Diabetes Mellitus, Type 2 - metabolism; Dysglycemia; FABP2; Fasting; Fatty Acid-Binding Proteins - metabolism; Humans; Inflammation; Intestinal permeability; Prediabetic State - metabolism; YKL-40
• ISSN: 1871-4021; 1878-0334
• DOI: 10.1016/j.dsx.2021.102366

Recent studies underlie the importance of intestinal permeability and chronic inflammation in the pathogenesis of T2DM. Our study compared the concentrations of FABP2 and YKL40 as markers of intestinal permeability and inflammation among normoglycemia, prediabetes and T2DM. We recruited 122 participants (45 normoglycemic, 26 prediabetes, and 51 T2DM) of whom we measured the fasting serum levels of FABP2 and YKL-40 using ELISA method. The levels of FABP2 were significantly higher in the T2DM group [2.890 (1.880–4.070)] in comparison to both prediabetes [2.025 (1.145–2.343), p = 0.0085] and normoglycemia group [1.72 (1.250–2.645), p = 0.011]. The levels of YKL-40 were also significantly higher in the T2DM group [68.70 (44.61–166.6)] in comparison to both prediabetes [28.85 (20.64–41.53), p