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Encapsulating quercetin in cyclodextrin metal–organic frameworks improved its solubility and bioavailability
BACKGROUND Quercetin (Que) has many pharmacological activities, such as anticancer, antioxidant, cardiovascular protection, antihypertensive and lipid‐lowering activities. However, its poor water solubility greatly limits its application in medicine and food. γ‐Cyclodextrin metal–organic frameworks...
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| Published in: | Journal of the science of food and agriculture 2022-07, Vol.102 (9), p.3887-3896 |
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| Main Authors: | , , , , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c3578-d145c4efa848c1822ee93613206a91efe21eda7bffe665559e7d8488898dee753 |
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| cites | cdi_FETCH-LOGICAL-c3578-d145c4efa848c1822ee93613206a91efe21eda7bffe665559e7d8488898dee753 |
| container_end_page | 3896 |
| container_issue | 9 |
| container_start_page | 3887 |
| container_title | Journal of the science of food and agriculture |
| container_volume | 102 |
| creator | Wang, Zhenjiong Ma, Yiding Jiang, Ying Zhou, Feng Wu, Yulong Jiang, Haitao Wang, Renlei Xu, Qing Hua, Chun |
| description | BACKGROUND
Quercetin (Que) has many pharmacological activities, such as anticancer, antioxidant, cardiovascular protection, antihypertensive and lipid‐lowering activities. However, its poor water solubility greatly limits its application in medicine and food. γ‐Cyclodextrin metal–organic frameworks (γ‐CD‐MOFs) are novel porous carriers for loading functional products. In this study, Que was successfully loaded into γ‐CD‐MOFs, and the new compound (Que‐CD‐MOFs) was characterised by X‐ray diffraction, infrared spectroscopy, thermogravimetric analysis and scanning electron microscopy.
RESULTS
The apparent solubility of Que‐CD‐MOFs was enhanced by 100‐fold compared with that of pure Que. The free radical scavenging ability of the encapsulated Que was significantly improved. The cytotoxicity of Que‐CD‐MOFs to HK‐2 cells was decreased, and their inhibition on HT‐29 tumour cells was maintained, as confirmed by CCK‐8 assays. Flow cytometry of HT‐29 cells showed that Que‐CD‐MOFs can inhibit G2 phase cells. Based on molecular modelling, Que molecules were preferentially located inside the cavities of γ‐CD pairs in γ‐CD‐MOFs.
CONCLUSION
γ‐CD‐MOFs are promising carriers for bioactive agents in food and pharmaceutical applications. © 2021 Society of Chemical Industry. |
| doi_str_mv | 10.1002/jsfa.11738 |
| format | article |
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Quercetin (Que) has many pharmacological activities, such as anticancer, antioxidant, cardiovascular protection, antihypertensive and lipid‐lowering activities. However, its poor water solubility greatly limits its application in medicine and food. γ‐Cyclodextrin metal–organic frameworks (γ‐CD‐MOFs) are novel porous carriers for loading functional products. In this study, Que was successfully loaded into γ‐CD‐MOFs, and the new compound (Que‐CD‐MOFs) was characterised by X‐ray diffraction, infrared spectroscopy, thermogravimetric analysis and scanning electron microscopy.
RESULTS
The apparent solubility of Que‐CD‐MOFs was enhanced by 100‐fold compared with that of pure Que. The free radical scavenging ability of the encapsulated Que was significantly improved. The cytotoxicity of Que‐CD‐MOFs to HK‐2 cells was decreased, and their inhibition on HT‐29 tumour cells was maintained, as confirmed by CCK‐8 assays. Flow cytometry of HT‐29 cells showed that Que‐CD‐MOFs can inhibit G2 phase cells. Based on molecular modelling, Que molecules were preferentially located inside the cavities of γ‐CD pairs in γ‐CD‐MOFs.
CONCLUSION
γ‐CD‐MOFs are promising carriers for bioactive agents in food and pharmaceutical applications. © 2021 Society of Chemical Industry.</description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.11738</identifier><identifier>PMID: 34952968</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Anticancer properties ; Antihypertensives ; Antioxidants ; Bioavailability ; Biocompatibility ; Cadmium ; Cholecystokinin ; Cyclodextrin ; Cyclodextrins ; Cytotoxicity ; Encapsulation ; Flow cytometry ; Food ; Free radicals ; G2 phase ; Infrared analysis ; Infrared spectroscopy ; Lipids ; Metal-organic frameworks ; metal–organic framework ; Molecular modelling ; Quercetin ; Scanning electron microscopy ; Scavenging ; Solubility ; Thermogravimetric analysis ; Toxicity ; Tumors ; water solubility ; γ‐cyclodextrin</subject><ispartof>Journal of the science of food and agriculture, 2022-07, Vol.102 (9), p.3887-3896</ispartof><rights>2021 Society of Chemical Industry.</rights><rights>Copyright © 2022 Society of Chemical Industry</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3578-d145c4efa848c1822ee93613206a91efe21eda7bffe665559e7d8488898dee753</citedby><cites>FETCH-LOGICAL-c3578-d145c4efa848c1822ee93613206a91efe21eda7bffe665559e7d8488898dee753</cites><orcidid>0000-0001-6297-0844 ; 0000-0002-3617-6732</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34952968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Zhenjiong</creatorcontrib><creatorcontrib>Ma, Yiding</creatorcontrib><creatorcontrib>Jiang, Ying</creatorcontrib><creatorcontrib>Zhou, Feng</creatorcontrib><creatorcontrib>Wu, Yulong</creatorcontrib><creatorcontrib>Jiang, Haitao</creatorcontrib><creatorcontrib>Wang, Renlei</creatorcontrib><creatorcontrib>Xu, Qing</creatorcontrib><creatorcontrib>Hua, Chun</creatorcontrib><title>Encapsulating quercetin in cyclodextrin metal–organic frameworks improved its solubility and bioavailability</title><title>Journal of the science of food and agriculture</title><addtitle>J Sci Food Agric</addtitle><description>BACKGROUND
Quercetin (Que) has many pharmacological activities, such as anticancer, antioxidant, cardiovascular protection, antihypertensive and lipid‐lowering activities. However, its poor water solubility greatly limits its application in medicine and food. γ‐Cyclodextrin metal–organic frameworks (γ‐CD‐MOFs) are novel porous carriers for loading functional products. In this study, Que was successfully loaded into γ‐CD‐MOFs, and the new compound (Que‐CD‐MOFs) was characterised by X‐ray diffraction, infrared spectroscopy, thermogravimetric analysis and scanning electron microscopy.
RESULTS
The apparent solubility of Que‐CD‐MOFs was enhanced by 100‐fold compared with that of pure Que. The free radical scavenging ability of the encapsulated Que was significantly improved. The cytotoxicity of Que‐CD‐MOFs to HK‐2 cells was decreased, and their inhibition on HT‐29 tumour cells was maintained, as confirmed by CCK‐8 assays. Flow cytometry of HT‐29 cells showed that Que‐CD‐MOFs can inhibit G2 phase cells. Based on molecular modelling, Que molecules were preferentially located inside the cavities of γ‐CD pairs in γ‐CD‐MOFs.
CONCLUSION
γ‐CD‐MOFs are promising carriers for bioactive agents in food and pharmaceutical applications. © 2021 Society of Chemical Industry.</description><subject>Anticancer properties</subject><subject>Antihypertensives</subject><subject>Antioxidants</subject><subject>Bioavailability</subject><subject>Biocompatibility</subject><subject>Cadmium</subject><subject>Cholecystokinin</subject><subject>Cyclodextrin</subject><subject>Cyclodextrins</subject><subject>Cytotoxicity</subject><subject>Encapsulation</subject><subject>Flow cytometry</subject><subject>Food</subject><subject>Free radicals</subject><subject>G2 phase</subject><subject>Infrared analysis</subject><subject>Infrared spectroscopy</subject><subject>Lipids</subject><subject>Metal-organic frameworks</subject><subject>metal–organic framework</subject><subject>Molecular modelling</subject><subject>Quercetin</subject><subject>Scanning electron microscopy</subject><subject>Scavenging</subject><subject>Solubility</subject><subject>Thermogravimetric analysis</subject><subject>Toxicity</subject><subject>Tumors</subject><subject>water solubility</subject><subject>γ‐cyclodextrin</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kctKxDAUhoMoznjZ-ABScCNCxyRt2mQ5DF4ZcKGuSyY9HTKmzZi06ux8B9_QJzFjRxcuhEByko-Pk_MjdETwiGBMzxe-kiNC8oRvoSHBIo8xJngbDcMjjRlJ6QDteb_AGAuRZbtokKSCUZHxIWouGiWXvjOy1c08eu7AKQjHKCy1UsaW8Na6UNTQSvP5_mHdXDZaRZWTNbxa9-QjXS-dfYEy0q2PvDXdTBvdriLZlNFMW_kitZH93QHaqaTxcLjZ99Hj5cXD5Dqe3l3dTMbTWCUs53FJUqZSqCRPuSKcUgCRZCShOJOCQAWUQCnzWVVBljHGBORlQDkXvATIWbKPTntv6Cz8ybdFrb0CY2QDtvMFzcJUkiQnNKAnf9CF7VwTugtUzgKF2Vp41lPKWe8dVMXS6Vq6VUFwsU6hWKdQfKcQ4OONspvVUP6iP2MPAOmBV21g9Y-quL2_HPfSL5aFlT4</recordid><startdate>202207</startdate><enddate>202207</enddate><creator>Wang, Zhenjiong</creator><creator>Ma, Yiding</creator><creator>Jiang, Ying</creator><creator>Zhou, Feng</creator><creator>Wu, Yulong</creator><creator>Jiang, Haitao</creator><creator>Wang, Renlei</creator><creator>Xu, Qing</creator><creator>Hua, Chun</creator><general>John Wiley & Sons, Ltd</general><general>John Wiley and Sons, Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QL</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6297-0844</orcidid><orcidid>https://orcid.org/0000-0002-3617-6732</orcidid></search><sort><creationdate>202207</creationdate><title>Encapsulating quercetin in cyclodextrin metal–organic frameworks improved its solubility and bioavailability</title><author>Wang, Zhenjiong ; Ma, Yiding ; Jiang, Ying ; Zhou, Feng ; Wu, Yulong ; Jiang, Haitao ; Wang, Renlei ; Xu, Qing ; Hua, Chun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3578-d145c4efa848c1822ee93613206a91efe21eda7bffe665559e7d8488898dee753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anticancer properties</topic><topic>Antihypertensives</topic><topic>Antioxidants</topic><topic>Bioavailability</topic><topic>Biocompatibility</topic><topic>Cadmium</topic><topic>Cholecystokinin</topic><topic>Cyclodextrin</topic><topic>Cyclodextrins</topic><topic>Cytotoxicity</topic><topic>Encapsulation</topic><topic>Flow cytometry</topic><topic>Food</topic><topic>Free radicals</topic><topic>G2 phase</topic><topic>Infrared analysis</topic><topic>Infrared spectroscopy</topic><topic>Lipids</topic><topic>Metal-organic frameworks</topic><topic>metal–organic framework</topic><topic>Molecular modelling</topic><topic>Quercetin</topic><topic>Scanning electron microscopy</topic><topic>Scavenging</topic><topic>Solubility</topic><topic>Thermogravimetric analysis</topic><topic>Toxicity</topic><topic>Tumors</topic><topic>water solubility</topic><topic>γ‐cyclodextrin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Zhenjiong</creatorcontrib><creatorcontrib>Ma, Yiding</creatorcontrib><creatorcontrib>Jiang, Ying</creatorcontrib><creatorcontrib>Zhou, Feng</creatorcontrib><creatorcontrib>Wu, Yulong</creatorcontrib><creatorcontrib>Jiang, Haitao</creatorcontrib><creatorcontrib>Wang, Renlei</creatorcontrib><creatorcontrib>Xu, Qing</creatorcontrib><creatorcontrib>Hua, Chun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Zhenjiong</au><au>Ma, Yiding</au><au>Jiang, Ying</au><au>Zhou, Feng</au><au>Wu, Yulong</au><au>Jiang, Haitao</au><au>Wang, Renlei</au><au>Xu, Qing</au><au>Hua, Chun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Encapsulating quercetin in cyclodextrin metal–organic frameworks improved its solubility and bioavailability</atitle><jtitle>Journal of the science of food and agriculture</jtitle><addtitle>J Sci Food Agric</addtitle><date>2022-07</date><risdate>2022</risdate><volume>102</volume><issue>9</issue><spage>3887</spage><epage>3896</epage><pages>3887-3896</pages><issn>0022-5142</issn><eissn>1097-0010</eissn><abstract>BACKGROUND
Quercetin (Que) has many pharmacological activities, such as anticancer, antioxidant, cardiovascular protection, antihypertensive and lipid‐lowering activities. However, its poor water solubility greatly limits its application in medicine and food. γ‐Cyclodextrin metal–organic frameworks (γ‐CD‐MOFs) are novel porous carriers for loading functional products. In this study, Que was successfully loaded into γ‐CD‐MOFs, and the new compound (Que‐CD‐MOFs) was characterised by X‐ray diffraction, infrared spectroscopy, thermogravimetric analysis and scanning electron microscopy.
RESULTS
The apparent solubility of Que‐CD‐MOFs was enhanced by 100‐fold compared with that of pure Que. The free radical scavenging ability of the encapsulated Que was significantly improved. The cytotoxicity of Que‐CD‐MOFs to HK‐2 cells was decreased, and their inhibition on HT‐29 tumour cells was maintained, as confirmed by CCK‐8 assays. Flow cytometry of HT‐29 cells showed that Que‐CD‐MOFs can inhibit G2 phase cells. Based on molecular modelling, Que molecules were preferentially located inside the cavities of γ‐CD pairs in γ‐CD‐MOFs.
CONCLUSION
γ‐CD‐MOFs are promising carriers for bioactive agents in food and pharmaceutical applications. © 2021 Society of Chemical Industry.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>34952968</pmid><doi>10.1002/jsfa.11738</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6297-0844</orcidid><orcidid>https://orcid.org/0000-0002-3617-6732</orcidid></addata></record> |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Anticancer properties Antihypertensives Antioxidants Bioavailability Biocompatibility Cadmium Cholecystokinin Cyclodextrin Cyclodextrins Cytotoxicity Encapsulation Flow cytometry Food Free radicals G2 phase Infrared analysis Infrared spectroscopy Lipids Metal-organic frameworks metal–organic framework Molecular modelling Quercetin Scanning electron microscopy Scavenging Solubility Thermogravimetric analysis Toxicity Tumors water solubility γ‐cyclodextrin |
| title | Encapsulating quercetin in cyclodextrin metal–organic frameworks improved its solubility and bioavailability |
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