Cardiovascular autonomic neuropathy and incident diabetic kidney disease in patients with type 2 diabetes

We investigated the association between cardiovascular autonomic neuropathy (CAN) and incident diabetic kidney disease (DKD). This retrospective longitudinal study included 2,033 patients with type 2 diabetes (mean age 57.2 years, 57.4% male, and median diabetes duration 8.0 years), free of renal dy...

Full description

Saved in:
Bibliographic Details
Published in:Diabetes research and clinical practice 2022-02, Vol.184, p.109181-109181, Article 109181
Main Authors: Eun Jun, Ji, Sun Choi, Min, Hyeon Kim, Jae
Format: Article
Language:English
Subjects:
Albuminuria - complications
Albuminuria - etiology
Cardiovascular autonomic neuropathy
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
Diabetic complications
Diabetic kidney disease
Diabetic Nephropathies - complications
Diabetic Nephropathies - etiology
Female
Glomerular Filtration Rate
Humans
Longitudinal Studies
Male
Middle Aged
Retrospective Studies
Risk Factors
Type 2 diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated the association between cardiovascular autonomic neuropathy (CAN) and incident diabetic kidney disease (DKD). This retrospective longitudinal study included 2,033 patients with type 2 diabetes (mean age 57.2 years, 57.4% male, and median diabetes duration 8.0 years), free of renal dysfunction or cardiovascular disease at initiation. Cardiovascular autonomic reflex tests were performed once at baseline, and CAN was defined as ≥ 2 abnormal parasympathetic test results. Urine ACR and eGFR were concurrently measured at baseline and every 3–6 months thereafter. Incident DKD was defined as the development of ACR ≥ 30 mg/g at two or more follow-up examinations or eGFR 
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2021.109181