Adenovirus vectors activate Vδ2+ γδT cells in a type I interferon‐, TNF‐, and IL‐18‐dependent manner

Vδ2+ γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2+ γδT cells in an interleukin 18‐, TNF‐, and type I interferon‐dependent manner. This stimulatory capacity was associated with adenovirus vectors of non‐species...

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Bibliographic Details
Published in:European journal of immunology 2022-05, Vol.52 (5), p.835-837
Main Authors: Provine, Nicholas M., Amini, Ali, Garner, Lucy C., FitzPatrick, Michael E.B., Dold, Christina, Silva Reyes, Laura, Chinnakannan, Senthil, Oguti, Blanche, Raymond, Meriel, Troise, Fulvia, Capone, Stefania, Folgori, Antonella, Barnes, Eleanor, Rollier, Christine S., Pollard, Andrew J., Klenerman, Paul
Format: Article
Language:English
Subjects:
Adenoviridae - genetics
Adenovirus
Adenoviruses
Cytokines
Expression vectors
Interferon
Interferon Type I
Interleukin 18
Lymphocytes T
Receptors, Antigen, T-Cell, gamma-delta - genetics
T cell receptors
T-Lymphocyte Subsets
Vaccines
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Summary:Vδ2+ γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2+ γδT cells in an interleukin 18‐, TNF‐, and type I interferon‐dependent manner. This stimulatory capacity was associated with adenovirus vectors of non‐species C origin, including the ChAdOx1 vaccine platform.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.202149367