Loading…
Percutaneous ablation of renal tumors versus surgical ablation and partial nephrectomy: Medicare trends and reimbursement cost comparison from 2010 to 2018
Purpose The purpose of this study is to analyze trends in Medicare volume and reimbursement for percutaneous and surgical ablation as well as laparoscopic and open partial nephrectomy for treatment of small renal tumors from 2010 to 2018. Methods Claims from the Medicare Part B Physician/Supplier Pr...
Saved in:
Published in: | Abdominal imaging 2022-02, Vol.47 (2), p.885-890 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c375t-fe8eb406f0ecee02a4c774c6624458d55357831760ad36796515f52c51be1d643 |
---|---|
cites | cdi_FETCH-LOGICAL-c375t-fe8eb406f0ecee02a4c774c6624458d55357831760ad36796515f52c51be1d643 |
container_end_page | 890 |
container_issue | 2 |
container_start_page | 885 |
container_title | Abdominal imaging |
container_volume | 47 |
creator | Patel, Vaidehi Lindquester, Will S. Dhangana, Rajoo Medsinge, Avinash |
description | Purpose
The purpose of this study is to analyze trends in Medicare volume and reimbursement for percutaneous and surgical ablation as well as laparoscopic and open partial nephrectomy for treatment of small renal tumors from 2010 to 2018.
Methods
Claims from the Medicare Part B Physician/Supplier Procedure Summary from 2010 to 2018 were extracted using CPT codes for percutaneous and surgical renal ablation and surgical and laparoscopic partial nephrectomy. Facility reimbursement and relative value units (RVUs) were obtained using the Centers for Medicare & Medicaid Services physician fee schedule look-up tool.
Results
Volume of percutaneous ablation increased from 2539 to 4571 procedures (80.0%). Specifically, percutaneous cryoablation became the dominant technique, increasing from 1434 to 2981 procedures (107.9%). Overall, volume of partial nephrectomy also increased by 40.4%, driven by an increase in laparoscopic partial nephrectomy from 3227 to 7770 procedures (140.8%) with a decrease in open partial nephrectomy from 3489 to 1661 (− 52.4%). Volume of surgical ablations also decreased 72.7% from 1260 to 344 procedures.
In 2018, reimbursement was $358.56 for percutaneous radiofrequency ablation, $481.32 for percutaneous cryoablation, $1216.43 for surgical radiofrequency ablation, $1269.35 for surgical cryoablation, $1381.67 for open partial nephrectomy, and $1552.66 for laparoscopic partial nephrectomy.
Conclusion
There has been a trend toward minimally invasive techniques for treatment of small renal tumors among Medicare patients. Laparoscopic partial nephrectomy has become the dominant treatment. In the setting of evidence showing comparable outcomes with surgery as well as lower costs to insurers, the volume of percutaneous ablation has also markedly increased. |
doi_str_mv | 10.1007/s00261-021-03390-4 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2614754420</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2624602863</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-fe8eb406f0ecee02a4c774c6624458d55357831760ad36796515f52c51be1d643</originalsourceid><addsrcrecordid>eNp9kctu1TAQhiMEolXbF2CBLLFhExhfk8MOVeUiFZUFSOwsx5mUVHF8GDtIfRZetk5TDhKLLnzRzDe_rf-vqhcc3nCA5m0CEIbXIMqScge1elIdC2lMDaDbp4e7-nFUnaV0AwDcaM6Ffl4dSbXTrQJ1XP35iuSX7GaMS2Kum1we48ziwAhnN7G8hEiJ_UZKpZ8Wuh59KR9AN_ds7yiPpTjj_iehzzHcvmNfsC8kIctFqE_3IOEYuoUSBpwz8zGtWyjjYypSA8XABHBgOa5ne1o9G9yU8OzhPKm-f7j4dv6pvrz6-Pn8_WXtZaNzPWCLnQIzAHpEEE75plHeGKGUbnutpW5ayRsDrpem2RUX9KCF17xD3hslT6rXm-6e4q8FU7ZhTB6naXPFFp9Vo5USUNBX_6E3caFi1EoJZUC0RhZKbJSnmBLhYPc0Bke3loNd07NberakZ-_Ts-svXj5IL13A_jDyN6sCyA1IpTVfI_17-xHZOx9GpW8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2624602863</pqid></control><display><type>article</type><title>Percutaneous ablation of renal tumors versus surgical ablation and partial nephrectomy: Medicare trends and reimbursement cost comparison from 2010 to 2018</title><source>Springer Link</source><creator>Patel, Vaidehi ; Lindquester, Will S. ; Dhangana, Rajoo ; Medsinge, Avinash</creator><creatorcontrib>Patel, Vaidehi ; Lindquester, Will S. ; Dhangana, Rajoo ; Medsinge, Avinash</creatorcontrib><description>Purpose
The purpose of this study is to analyze trends in Medicare volume and reimbursement for percutaneous and surgical ablation as well as laparoscopic and open partial nephrectomy for treatment of small renal tumors from 2010 to 2018.
Methods
Claims from the Medicare Part B Physician/Supplier Procedure Summary from 2010 to 2018 were extracted using CPT codes for percutaneous and surgical renal ablation and surgical and laparoscopic partial nephrectomy. Facility reimbursement and relative value units (RVUs) were obtained using the Centers for Medicare & Medicaid Services physician fee schedule look-up tool.
Results
Volume of percutaneous ablation increased from 2539 to 4571 procedures (80.0%). Specifically, percutaneous cryoablation became the dominant technique, increasing from 1434 to 2981 procedures (107.9%). Overall, volume of partial nephrectomy also increased by 40.4%, driven by an increase in laparoscopic partial nephrectomy from 3227 to 7770 procedures (140.8%) with a decrease in open partial nephrectomy from 3489 to 1661 (− 52.4%). Volume of surgical ablations also decreased 72.7% from 1260 to 344 procedures.
In 2018, reimbursement was $358.56 for percutaneous radiofrequency ablation, $481.32 for percutaneous cryoablation, $1216.43 for surgical radiofrequency ablation, $1269.35 for surgical cryoablation, $1381.67 for open partial nephrectomy, and $1552.66 for laparoscopic partial nephrectomy.
Conclusion
There has been a trend toward minimally invasive techniques for treatment of small renal tumors among Medicare patients. Laparoscopic partial nephrectomy has become the dominant treatment. In the setting of evidence showing comparable outcomes with surgery as well as lower costs to insurers, the volume of percutaneous ablation has also markedly increased.</description><identifier>ISSN: 2366-004X</identifier><identifier>EISSN: 2366-0058</identifier><identifier>DOI: 10.1007/s00261-021-03390-4</identifier><identifier>PMID: 34958404</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Ablation ; Aged ; Catheter Ablation - methods ; Costs and Cost Analysis ; Gastroenterology ; Government programs ; Hepatology ; Humans ; Imaging ; Interventional Radiology ; Kidney cancer ; Kidney Neoplasms - pathology ; Kidney Neoplasms - surgery ; Kidneys ; Laparoscopy ; Medicare ; Medicine ; Medicine & Public Health ; Nephrectomy ; Nephrectomy - methods ; Radio frequency ; Radiology ; Reimbursement ; Trends ; Tumors ; United States</subject><ispartof>Abdominal imaging, 2022-02, Vol.47 (2), p.885-890</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-fe8eb406f0ecee02a4c774c6624458d55357831760ad36796515f52c51be1d643</citedby><cites>FETCH-LOGICAL-c375t-fe8eb406f0ecee02a4c774c6624458d55357831760ad36796515f52c51be1d643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34958404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Vaidehi</creatorcontrib><creatorcontrib>Lindquester, Will S.</creatorcontrib><creatorcontrib>Dhangana, Rajoo</creatorcontrib><creatorcontrib>Medsinge, Avinash</creatorcontrib><title>Percutaneous ablation of renal tumors versus surgical ablation and partial nephrectomy: Medicare trends and reimbursement cost comparison from 2010 to 2018</title><title>Abdominal imaging</title><addtitle>Abdom Radiol</addtitle><addtitle>Abdom Radiol (NY)</addtitle><description>Purpose
The purpose of this study is to analyze trends in Medicare volume and reimbursement for percutaneous and surgical ablation as well as laparoscopic and open partial nephrectomy for treatment of small renal tumors from 2010 to 2018.
Methods
Claims from the Medicare Part B Physician/Supplier Procedure Summary from 2010 to 2018 were extracted using CPT codes for percutaneous and surgical renal ablation and surgical and laparoscopic partial nephrectomy. Facility reimbursement and relative value units (RVUs) were obtained using the Centers for Medicare & Medicaid Services physician fee schedule look-up tool.
Results
Volume of percutaneous ablation increased from 2539 to 4571 procedures (80.0%). Specifically, percutaneous cryoablation became the dominant technique, increasing from 1434 to 2981 procedures (107.9%). Overall, volume of partial nephrectomy also increased by 40.4%, driven by an increase in laparoscopic partial nephrectomy from 3227 to 7770 procedures (140.8%) with a decrease in open partial nephrectomy from 3489 to 1661 (− 52.4%). Volume of surgical ablations also decreased 72.7% from 1260 to 344 procedures.
In 2018, reimbursement was $358.56 for percutaneous radiofrequency ablation, $481.32 for percutaneous cryoablation, $1216.43 for surgical radiofrequency ablation, $1269.35 for surgical cryoablation, $1381.67 for open partial nephrectomy, and $1552.66 for laparoscopic partial nephrectomy.
Conclusion
There has been a trend toward minimally invasive techniques for treatment of small renal tumors among Medicare patients. Laparoscopic partial nephrectomy has become the dominant treatment. In the setting of evidence showing comparable outcomes with surgery as well as lower costs to insurers, the volume of percutaneous ablation has also markedly increased.</description><subject>Ablation</subject><subject>Aged</subject><subject>Catheter Ablation - methods</subject><subject>Costs and Cost Analysis</subject><subject>Gastroenterology</subject><subject>Government programs</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Interventional Radiology</subject><subject>Kidney cancer</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Kidneys</subject><subject>Laparoscopy</subject><subject>Medicare</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrectomy</subject><subject>Nephrectomy - methods</subject><subject>Radio frequency</subject><subject>Radiology</subject><subject>Reimbursement</subject><subject>Trends</subject><subject>Tumors</subject><subject>United States</subject><issn>2366-004X</issn><issn>2366-0058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kctu1TAQhiMEolXbF2CBLLFhExhfk8MOVeUiFZUFSOwsx5mUVHF8GDtIfRZetk5TDhKLLnzRzDe_rf-vqhcc3nCA5m0CEIbXIMqScge1elIdC2lMDaDbp4e7-nFUnaV0AwDcaM6Ffl4dSbXTrQJ1XP35iuSX7GaMS2Kum1we48ziwAhnN7G8hEiJ_UZKpZ8Wuh59KR9AN_ds7yiPpTjj_iehzzHcvmNfsC8kIctFqE_3IOEYuoUSBpwz8zGtWyjjYypSA8XABHBgOa5ne1o9G9yU8OzhPKm-f7j4dv6pvrz6-Pn8_WXtZaNzPWCLnQIzAHpEEE75plHeGKGUbnutpW5ayRsDrpem2RUX9KCF17xD3hslT6rXm-6e4q8FU7ZhTB6naXPFFp9Vo5USUNBX_6E3caFi1EoJZUC0RhZKbJSnmBLhYPc0Bke3loNd07NberakZ-_Ts-svXj5IL13A_jDyN6sCyA1IpTVfI_17-xHZOx9GpW8</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Patel, Vaidehi</creator><creator>Lindquester, Will S.</creator><creator>Dhangana, Rajoo</creator><creator>Medsinge, Avinash</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K7-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20220201</creationdate><title>Percutaneous ablation of renal tumors versus surgical ablation and partial nephrectomy: Medicare trends and reimbursement cost comparison from 2010 to 2018</title><author>Patel, Vaidehi ; Lindquester, Will S. ; Dhangana, Rajoo ; Medsinge, Avinash</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-fe8eb406f0ecee02a4c774c6624458d55357831760ad36796515f52c51be1d643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Ablation</topic><topic>Aged</topic><topic>Catheter Ablation - methods</topic><topic>Costs and Cost Analysis</topic><topic>Gastroenterology</topic><topic>Government programs</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Imaging</topic><topic>Interventional Radiology</topic><topic>Kidney cancer</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Kidneys</topic><topic>Laparoscopy</topic><topic>Medicare</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrectomy</topic><topic>Nephrectomy - methods</topic><topic>Radio frequency</topic><topic>Radiology</topic><topic>Reimbursement</topic><topic>Trends</topic><topic>Tumors</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Vaidehi</creatorcontrib><creatorcontrib>Lindquester, Will S.</creatorcontrib><creatorcontrib>Dhangana, Rajoo</creatorcontrib><creatorcontrib>Medsinge, Avinash</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Computer Science Collection</collection><collection>Computer Science Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Abdominal imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Vaidehi</au><au>Lindquester, Will S.</au><au>Dhangana, Rajoo</au><au>Medsinge, Avinash</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Percutaneous ablation of renal tumors versus surgical ablation and partial nephrectomy: Medicare trends and reimbursement cost comparison from 2010 to 2018</atitle><jtitle>Abdominal imaging</jtitle><stitle>Abdom Radiol</stitle><addtitle>Abdom Radiol (NY)</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>47</volume><issue>2</issue><spage>885</spage><epage>890</epage><pages>885-890</pages><issn>2366-004X</issn><eissn>2366-0058</eissn><abstract>Purpose
The purpose of this study is to analyze trends in Medicare volume and reimbursement for percutaneous and surgical ablation as well as laparoscopic and open partial nephrectomy for treatment of small renal tumors from 2010 to 2018.
Methods
Claims from the Medicare Part B Physician/Supplier Procedure Summary from 2010 to 2018 were extracted using CPT codes for percutaneous and surgical renal ablation and surgical and laparoscopic partial nephrectomy. Facility reimbursement and relative value units (RVUs) were obtained using the Centers for Medicare & Medicaid Services physician fee schedule look-up tool.
Results
Volume of percutaneous ablation increased from 2539 to 4571 procedures (80.0%). Specifically, percutaneous cryoablation became the dominant technique, increasing from 1434 to 2981 procedures (107.9%). Overall, volume of partial nephrectomy also increased by 40.4%, driven by an increase in laparoscopic partial nephrectomy from 3227 to 7770 procedures (140.8%) with a decrease in open partial nephrectomy from 3489 to 1661 (− 52.4%). Volume of surgical ablations also decreased 72.7% from 1260 to 344 procedures.
In 2018, reimbursement was $358.56 for percutaneous radiofrequency ablation, $481.32 for percutaneous cryoablation, $1216.43 for surgical radiofrequency ablation, $1269.35 for surgical cryoablation, $1381.67 for open partial nephrectomy, and $1552.66 for laparoscopic partial nephrectomy.
Conclusion
There has been a trend toward minimally invasive techniques for treatment of small renal tumors among Medicare patients. Laparoscopic partial nephrectomy has become the dominant treatment. In the setting of evidence showing comparable outcomes with surgery as well as lower costs to insurers, the volume of percutaneous ablation has also markedly increased.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34958404</pmid><doi>10.1007/s00261-021-03390-4</doi><tpages>6</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2366-004X |
ispartof | Abdominal imaging, 2022-02, Vol.47 (2), p.885-890 |
issn | 2366-004X 2366-0058 |
language | eng |
recordid | cdi_proquest_miscellaneous_2614754420 |
source | Springer Link |
subjects | Ablation Aged Catheter Ablation - methods Costs and Cost Analysis Gastroenterology Government programs Hepatology Humans Imaging Interventional Radiology Kidney cancer Kidney Neoplasms - pathology Kidney Neoplasms - surgery Kidneys Laparoscopy Medicare Medicine Medicine & Public Health Nephrectomy Nephrectomy - methods Radio frequency Radiology Reimbursement Trends Tumors United States |
title | Percutaneous ablation of renal tumors versus surgical ablation and partial nephrectomy: Medicare trends and reimbursement cost comparison from 2010 to 2018 |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T22%3A02%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Percutaneous%20ablation%20of%20renal%20tumors%20versus%20surgical%20ablation%20and%20partial%20nephrectomy:%20Medicare%20trends%20and%20reimbursement%20cost%20comparison%20from%202010%20to%202018&rft.jtitle=Abdominal%20imaging&rft.au=Patel,%20Vaidehi&rft.date=2022-02-01&rft.volume=47&rft.issue=2&rft.spage=885&rft.epage=890&rft.pages=885-890&rft.issn=2366-004X&rft.eissn=2366-0058&rft_id=info:doi/10.1007/s00261-021-03390-4&rft_dat=%3Cproquest_cross%3E2624602863%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c375t-fe8eb406f0ecee02a4c774c6624458d55357831760ad36796515f52c51be1d643%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2624602863&rft_id=info:pmid/34958404&rfr_iscdi=true |