Cyanoacrylate glue in socket repair: a comparative study

• Published in: British journal of oral & maxillofacial surgery 2022-02, Vol.60 (2), p.145-151
• Main Authors: Maia, G.V., Sousa, C.W., de Lima, J.C.R., Vecchio, J.L., de Barros Silva, P.G., de Souza Carvalho, A.C.G.
• Format: Article
• Language: English
• Subjects: Animals; Bone biology; Bone remodelling/regeneration; Cyanoacrylates - therapeutic use; Humans; Male; Nylons; Rats; Rats, Wistar; Surgery; Sutures; Tooth Socket - surgery
• ISSN: 0266-4356; 1532-1940
• DOI: 10.1016/j.bjoms.2021.01.017

This study aimed to compare socket repair with Nylon 5-0 suture and closure using cyanoacrylate biological glue after tooth extraction. Twenty male Wistar rats, each weighing approximately 200 g were submitted to the extraction of the right and left first molar teeth. On the right side, the alveolus was closed with 2 ethyl-cyanoacrylate glue, whereas on the left side closure was with a single interrupted Nylon 5-0 suture (Ethilon). The animals were sacrificed after 3, 7, 15, and 30 postoperative days, and images of histological sections of the alveolus were captured for analysis. Histomorphometry was performed using Image J software to quantify bone neoformation in the alveolus. The results showed that on the seventh postoperative day the side treated with 2-ethyl-cyanoacrylate presented a delay in relation to the sutured side. However, on days 15 and 30, the difference in bone neoformation between gradually decreased until the thirtieth postoperative day, with no significant difference in bone neoformation in the last period of analysis. There was no difference between neoformation in the two sides (p = 0.902) after statistical analysis of the histomorphometric results. In conclusion, socket repair after alveolus closure with 2-ethyl-cyanoacrylate allows complete bone neoformation after tooth extraction, and there is no significant difference when compared with closure with Nylon 5-0.