Patient reported outcomes after risk-reducing surgery in patients at increased risk of ovarian cancer

• Published in: Gynecologic oncology 2022-02, Vol.164 (2), p.421-427
• Main Authors: Philp, L., Alimena, S., Ferris, W., Saini, A., Bregar, A.J., del Carmen, M.G., Eisenhauer, E.L., Growdon, W.B., Goodman, A., Dorney, K., Mazina, V., Sisodia, R.C.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Anxiety - psychology; Body Dissatisfaction - psychology; Carcinoma, Ovarian Epithelial - genetics; Carcinoma, Ovarian Epithelial - prevention & control; Carcinoma, Ovarian Epithelial - psychology; Carcinoma, Ovarian Epithelial - surgery; Colorectal Neoplasms, Hereditary Nonpolyposis - genetics; Colorectal Neoplasms, Hereditary Nonpolyposis - psychology; Colorectal Neoplasms, Hereditary Nonpolyposis - surgery; Female; Hereditary Breast and Ovarian Cancer Syndrome - genetics; Hereditary Breast and Ovarian Cancer Syndrome - psychology; Hereditary Breast and Ovarian Cancer Syndrome - surgery; Humans; Middle Aged; Outcome measures; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - prevention & control; Ovarian Neoplasms - psychology; Ovarian Neoplasms - surgery; Patient reported; Patient Reported Outcome Measures; Patient reported outcomes; Prophylactic Surgical Procedures; Quality improvement; Quality of Life; Risk-reducing surgery; Salpingo-oophorectomy; Sexual Dysfunction, Physiological - physiopathology; Young Adult
• ISSN: 0090-8258; 1095-6859
• DOI: 10.1016/j.ygyno.2021.12.017

To describe the quality of life of women at an increased risk of ovarian cancer undergoing risk-reducing bilateral salpingo-oophorectomy (RRBSO). Patients evaluated in our gynecologic oncology ambulatory practice between January 2018–December 2019 for an increased risk of ovarian cancer were included. Patients received the EORTC QLQ-C30 and PROMIS emotional and instrumental support questionnaires along with a disease-specific measure (PROM). First and last and pre- and post-surgical PROM responses in each group were compared as were PROMs between at-risk patients and patients with other ovarian diseases. 195 patients with an increased risk of ovarian cancer were identified, 155 completed PROMs (79.5%). BRCA1 or BRCA2 mutations were noted in 52.8%. Also included were 469 patients with benign ovarian disease and 455 with ovarian neoplasms. Seventy-two at-risk patients (46.5%) had surgery and 36 had both pre- and post-operative PROMs. Post-operatively, these patients reported significantly less tension (p = 0.011) and health-related worry (p = 0.021) but also decreased levels of health (p = 0.018) and quality of life