Maternal infection during pregnancy and the risk of attention-deficit/hyperactivity disorder in the offspring: A systematic review and meta-analysis

The effects of maternal infection during pregnancy on the risk of attention-deficit/hyperactivity disorder (ADHD) in the offspring are unclear, and no overview is available. We searched the PubMed and EMBASE databases for relevant studies and performed a systematic review and meta-analysis of the li...

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Bibliographic Details
Published in:Asian journal of psychiatry 2022-02, Vol.68, p.102972-102972, Article 102972
Main Authors: Zhu, Chun-yan, Jiang, Hai-yin, Sun, Ji-jun
Format: Article
Language:English
Subjects:
Attention Deficit Disorder with Hyperactivity - epidemiology
Attention Deficit Disorder with Hyperactivity - etiology
Databases, Factual
Female
Fever
Humans
Infectious
Meta-analysis
Neurodevelopment
Pregnancy
Prenatal Exposure Delayed Effects - epidemiology
Siblings
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Summary:The effects of maternal infection during pregnancy on the risk of attention-deficit/hyperactivity disorder (ADHD) in the offspring are unclear, and no overview is available. We searched the PubMed and EMBASE databases for relevant studies and performed a systematic review and meta-analysis of the literature. We found that that maternal infection during pregnancy was associated with a small increase in the risk of ADHD (OR 1.25, 95% CI 1.09, 1.44, P 
ISSN:1876-2018
1876-2026
DOI:10.1016/j.ajp.2021.102972