The molecular link between oxidative stress, insulin resistance, and type 2 diabetes: A target for new therapies against cardiovascular diseases

Type 2 Diabetes Mellitus (T2D) is a chronic disease with a pandemic incidence whose pathogenesis has not yet been clarified. Raising evidence highlighted the role of oxidative stress in inducing insulin resistance, pancreatic beta-cell dysfunction, and leading to cardiovascular disease (CVD). Theref...

Full description

Saved in:
Bibliographic Details
Published in:Current opinion in pharmacology 2022-02, Vol.62, p.85-96
Main Authors: Andreadi, Aikaterini, Bellia, Alfonso, Di Daniele, Nicola, Meloni, Marco, Lauro, Renato, Della-Morte, David, Lauro, Davide
Format: Article
Language:English
Subjects:
Antioxidants - therapeutic use
Cardiovascular Diseases - drug therapy
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - pathology
Humans
Insulin
Insulin Resistance
Oxidative Stress
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Type 2 Diabetes Mellitus (T2D) is a chronic disease with a pandemic incidence whose pathogenesis has not yet been clarified. Raising evidence highlighted the role of oxidative stress in inducing insulin resistance, pancreatic beta-cell dysfunction, and leading to cardiovascular disease (CVD). Therefore, understanding the link between oxidative stress, T2D and CVD may help to further understand the pathological processes beyond this association, to personalize the algorithm of the cure, and to find new therapeutic targets. Here, we discussed the role of oxidative stress and the decrease of antioxidant defenses in the pathogenesis of T2D. Furthermore, some aspects of hypoglycemic therapies and their potential role as antioxidant agents were examined, which might be pivotal in preventing CVD in T2D patients.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2021.11.010