Antibacterial sesquiterpenoids from Solanum lyratum

Investigation into the chemical diversity of led to the discovery of one new sesquiterpenoid, solyraterpenoid A ( ), and two known compounds ( and ). The structure incorporating absolute configuration of was determined via spectroscopic data, mainly including HRESIMS and NMR, and single-crystal X-ra...

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Bibliographic Details
Published in:Natural product research 2022-11, Vol.36 (22), p.1-5867
Main Authors: Liang, Jun, Liang, Wenbin, Chen, Xintao, Wang, Qibin
Format: Article
Language:English
Subjects:
Absolute configuration
Antibacterial activity
E coli
Klebsiella
NMR
Nuclear magnetic resonance
Pseudomonas aeruginosa
Sesquiterpenoids
Single crystals
Solanum lyratum
X-ray diffraction
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Summary:Investigation into the chemical diversity of led to the discovery of one new sesquiterpenoid, solyraterpenoid A ( ), and two known compounds ( and ). The structure incorporating absolute configuration of was determined via spectroscopic data, mainly including HRESIMS and NMR, and single-crystal X-ray diffraction analysis. Compound showed significant antibacterial activity against , , and with MIC values of 8, 8, and 4  g/mL, respectively.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.2019734