PHOX2B as a Reliable Marker for Neuroblastoma in Tissue and Cytology Specimens

Abstract To investigate the diagnostic utility of immunohistochemistry for paired-like homeobox 2B (PHOX2B) expression in neuroblastomas (NBs) and tumors that mimic them, tissue samples (n = 229) from 157 cases of NB, 210 central nervous system tumors, and 170 extracranial non-NB solid tumors (n = 1...

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Published in:Journal of neuropathology and experimental neurology 2021-12, Vol.80 (12), p.1108-1116
Main Authors: Ma, Yangyang, Feng, Jiayan, Zhao, Jing, Ding, Di, Tian, Feng, Chen, Lian, Zheng, Jicui, Xiao, Xianmin
Format: Article
Language:English
Subjects:
Biological markers
Biomarkers, Tumor - analysis
Biomarkers, Tumor - metabolism
Cancer
Cellular biology
Diagnosis
Diagnostic immunohistochemistry
Genetic aspects
Health aspects
Homeodomain Proteins - analysis
Homeodomain Proteins - metabolism
Humans
Immunohistochemistry
Neuroblastoma
Neuroblastoma - diagnosis
Oncology, Experimental
Transcription factors
Transcription Factors - analysis
Transcription Factors - metabolism
Tumors in children
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Summary:Abstract To investigate the diagnostic utility of immunohistochemistry for paired-like homeobox 2B (PHOX2B) expression in neuroblastomas (NBs) and tumors that mimic them, tissue samples (n = 229) from 157 cases of NB, 210 central nervous system tumors, and 170 extracranial non-NB solid tumors (n = 170) were immunostained for PHOX2B. Additionally, PHOX2B expression in 67 body fluid cytology specimens was analyzed. In tissue specimens, PHOX2B expression was positive in NBs, pheochromocytomas, and paragangliomas but negative in all of the other tumors evaluated. PHOX2B was detected by immunohistochemistry in 5 NB cytology specimens; all of the others were negative. These results suggest that PHOX2B may be a sensitive and specific immunohistochemical marker for the pathological diagnosis and differential diagnosis of NB in both tissue and cytology specimens.
ISSN:0022-3069
1554-6578
DOI:10.1093/jnen/nlab112