Adaptation to Antimicrobials and Pathogenicity in Mycoplasmas: Development of Ciprofloxacin-Resistance and Evolution of Virulence in Acholeplasma laidlawii

For the first time it was shown that the development of resistance to ciprofloxacin in vitro in Acholeplasma laidlawii , a mycoplasma which is widely spread in nature and which is the main contaminant of cell cultures and vaccines, is associated with diverse pathways of virulence evolution: virulome...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2021-11, Vol.501 (1), p.444-448
Main Authors: Medvedeva, E. S., Mouzykantov, A. A., Kostenko, V. V., Baranova, N. B., Markelova, M. I., Sabouni, R. G., Khusnutdinova, D. R., Chernova, O. A., Chernov, V. M.
Format: Article
Language:English
Subjects:
Acholeplasma laidlawii - drug effects
Acholeplasma laidlawii - genetics
Acholeplasma laidlawii - pathogenicity
Adaptation, Physiological
Anti-Bacterial Agents - pharmacology
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Ciprofloxacin
Ciprofloxacin - pharmacology
Contaminants
Drug Resistance, Bacterial
Life Sciences
Molecular Biology
Pathogenicity
Virulence
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Summary:For the first time it was shown that the development of resistance to ciprofloxacin in vitro in Acholeplasma laidlawii , a mycoplasma which is widely spread in nature and which is the main contaminant of cell cultures and vaccines, is associated with diverse pathways of virulence evolution: virulome and virulence differ significantly between ciprofloxacin-resistant strains, including those with the same level of antimicrobial resistance.
ISSN:1607-6729
1608-3091
1608-3091
DOI:10.1134/S1607672921060028