Paediatric Anogenital Condylomata Acuminata: An assessment of patient characteristics and the need for surgical intervention

• Published in: Journal of pediatric surgery 2022-04, Vol.57 (4), p.715-718
• Main Authors: Langham, Alice Rose, Gabler, Tarryn, Bebington, Catterina, Brisighelli, Giulia, Westgarth-Taylor, Chris
• Format: Article
• Language: English
• Subjects: Adult; Anogenital warts; Cauterization; Child; Child, Preschool; Condylomata Acuminata - diagnosis; Condylomata Acuminata - epidemiology; Condylomata Acuminata - surgery; HIV; HPV; Humans; Immunocompromise; Papillomavirus Infections - complications; Papillomavirus Infections - epidemiology; Sexual Behavior
• ISSN: 0022-3468; 1531-5037
• DOI: 10.1016/j.jpedsurg.2021.11.027

Anogenital Condylomata Acuminata (AGCA) are caused by Human Papilloma Virus (HPV), which is one of the most common sexually transmitted illnesses in adults. Although commonly seen in the paediatric population, especially in the setting of immunocompromise, literature regarding transmission, viral type and management in this population is scant. The aim of this study was to assess the profile of patients presenting with anogenital warts in light of associated immunocompromise with Human Immunodeficiency Virus (HIV). Three years of patient records from Chis Hani Baragwanath Academic Hospital were reviewed (January 2017 – December 2019). Information collected included: gender, age of presentation, age at intervention, type and duration of medical treatment, type and number of surgical interventions, HIV status, and histology results. Fisher's and Pearson's test were used to assess correlation between immune status and surgical interventions necessary. In the time frame considered, we treated 66 patients with AGCA . The average age was 4 years old (1–14). HIV status was recorded in 30 patients (15 positive and 15 negative). Only one patient out of 66 had a history of sexual abuse. Whilst the proportion of patients who required surgical intervention in the HIV negative and HIV positive groups was equal (2:1), the total number of surgical interventions needed to achieve clearance was significantly more in those with HIV (p = 0.03). HIV positive patients with AGCA require more surgical interventions compared to HIV negative individuals. Further research will be conducted to ascertain the sub-type of HPV infection in this subset of patients and to assess if this impacts follow-up for future malignancy. Further research also needs to be conducted to ascertain whether surgical intervention should be instituted earlier in the treatment protocol for HIV positive children.