High-density lipoprotein cholesterol and cardiovascular mortality: a prospective cohort study among 15.8 million adults

We aimed to investigate whether the associations between high-density lipoprotein cholesterol (HDL-C) and cardiovascular disease (CVD) mortality and the optimal range differ by age and CVD subtypes. Korean adults (n = 15 859 501) with no CVD/cancer who received routine health examinations during 200...

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Published in:European journal of preventive cardiology 2022-05, Vol.29 (5), p.844-854
Main Authors: Yi, Sang-Wook, Park, Hyung-Bok, Jung, Mi-Hyang, Yi, Jee-Jeon, Ohrr, Heechoul
Format: Article
Language:English
Subjects:
Adult
Cardiovascular Diseases - epidemiology
Cholesterol, HDL
Humans
Proportional Hazards Models
Prospective Studies
Risk Factors
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Summary:We aimed to investigate whether the associations between high-density lipoprotein cholesterol (HDL-C) and cardiovascular disease (CVD) mortality and the optimal range differ by age and CVD subtypes. Korean adults (n = 15 859 501) with no CVD/cancer who received routine health examinations during 2009-2010 were followed until 2018 for CVD mortality. During a mean 8.8 years of follow-up, 108 123 individuals died from CVD. U-curve associations were found between HDL-C and CVD mortality, regardless of sex, age, and CVD subtype. The optimal range was 50-79 mg/dL (1.29-2.06 mmol/L), while it was 40-69 (1.03-1.80), 50-79 (1.29-2.06), and 60-89 (1.55-2.32) mg/dL (mmol/L) in adults aged
ISSN:2047-4873
2047-4881
DOI:10.1093/eurjpc/zwab230