Hematologic Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference

Studies of organ dysfunction in children are limited by a lack of consensus around organ dysfunction criteria. To derive evidence-informed, consensus-based criteria for hematologic dysfunction in critically ill children. Data sources included PubMed and Embase from January 1992 to January 2020. Stud...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2022-01, Vol.149 (1 Suppl 1), p.S74-S78
Main Authors: Muszynski, Jennifer A, Cholette, Jill M, Steiner, Marie E, Tucci, Marisa, Doctor, Allan, Parker, Robert I
Format: Article
Language:English
Subjects:
Blood diseases
Child
Children
Critical Illness
Critically ill children
Demographic aspects
Development and progression
Diagnosis
Etiology
Evaluation
Hematologic diseases
Hematologic Diseases - diagnosis
Hematologic Diseases - physiopathology
Hemoglobin
Hemoglobinometry
Humans
Leukocyte Count
Mortality
Multiple Organ Failure - diagnosis
Multiple Organ Failure - physiopathology
Pediatrics
Platelet Count
Platelets
Practice guidelines (Medicine)
Prognosis
Risk Factors
Severity of Illness Index
Thrombocytopenia
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Summary:Studies of organ dysfunction in children are limited by a lack of consensus around organ dysfunction criteria. To derive evidence-informed, consensus-based criteria for hematologic dysfunction in critically ill children. Data sources included PubMed and Embase from January 1992 to January 2020. Studies were included if they evaluated assessment/scoring tools to screen for hematologic dysfunction and assessed outcomes of mortality, functional status, organ-specific outcomes, or other patient-centered outcomes. Studies of adults or premature infants, animal studies, reviews/commentaries, small case series, and non-English language studies with inability to determine eligibility were excluded. Data were abstracted from each eligible study into a standard data extraction form along with risk of bias assessment. Twenty-nine studies were included. The systematic review supports the following criteria for hematologic dysfunction: thrombocytopenia (platelet count
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2021-052888K