2D→3D Polycatenated Cu(I) Coordination Polymer: Photocatalytic Property and Protective Activity on COPD by Reducing the INF-γ Production

• Published in: Journal of fluorescence 2022, Vol.32 (1), p.397-404
• Main Authors: Zhu, Jun-Fei, Yang, Wei-Wei, Yang, Jian, Jin, Li-Tong
• Format: Article
• Language: English
• Subjects: Analytical Chemistry; Animals; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biomedicine; Biophysics; Biotechnology; Catalysis; Coordination polymers; Copper - chemistry; Copper - pharmacology; Dimethylformamide; Epithelial Cells - metabolism; Epithelium; Humans; Interferon-gamma - metabolism; Lethal Dose 50; Light irradiation; Mice; NF-kappa B - metabolism; Original Article; Photocatalysis; Photochemical Processes; Polymers; Pulmonary Disease, Chronic Obstructive - metabolism; Real-Time Polymerase Chain Reaction; Respiratory Mucosa - cytology; Respiratory Mucosa - metabolism; Signal Transduction; X-Ray Diffraction
• ISSN: 1053-0509; 1573-4994
• DOI: 10.1007/s10895-021-02850-w

Reported here is a new [Cu 4 I 4 ] cluster-based coordination polymer, namely [Cu 4 I 4 (bib) 2 ] n ·n(DMF) ( 1 , bib = 1,4-bis(imidazolyl)butane, DMF = N,N’-dimethylformamide), which was synthesized by the self-assemble reaction of CuI, bib and KI under solvothermal conditions. Remarkably, compound 1 shows promising photocatalytic performance toward to the degradation of MB solution under visible light irradiation. For the COPD treatment, the ELISA detection kit was conducted to determine the content of INF-γ released by the respiratory tract mucosal epithelial cells. In addition to this, the activation levels of the NF-κB signaling pathway were still need to be assessed by the real time RT-PCR after the compound treatment.