Serum 8-Hydroxy-2′-deoxyguanosine Predicts Severity and Prognosis of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

• Published in: Lung 2022-02, Vol.200 (1), p.31-39
• Main Authors: Cao, Peng, Zhang, Chen, Hua, Dong-Xu, Li, Meng-Die, Lv, Bian-Bian, Fu, Lin, Zhao, Hui
• Format: Article
• Language: English
• Subjects: 8-Hydroxy-2'-Deoxyguanosine; 8-Hydroxydeoxyguanosine; Analysis; Biomarkers; Chronic obstructive pulmonary disease; Cohort analysis; COPD; Correlation; Cytokines; Deoxyguanosine; Development and progression; Disease Progression; Enzyme-linked immunosorbent assay; Hospital patients; Humans; Inflammation; Length of stay; Lung; Lung diseases; Lung diseases, Obstructive; Medical prognosis; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Obstructive lung disease; Oxidative Stress; Pathogenesis; Patients; Pneumology/Respiratory System; Prognosis; Pulmonary Disease, Chronic Obstructive; Pulmonary functions; Regression analysis; Respiratory function; Risk analysis; Risk factors
• ISSN: 0341-2040; 1432-1750
• DOI: 10.1007/s00408-021-00507-w

Background Oxidative stress is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). 8-Hydroxy-2′-deoxyguanosine (8-OHdG) is recognized as a biomarker of oxidative stress and is implicated in several pulmonary diseases. Nonetheless, the role of 8-OHdG remains unclear in COPD patients. This research aimed to evaluate the correlations between serum 8-OHdG on admission and the severity and prognosis of hospitalized COPD patients with acute exacerbation. Methods A total of 150 COPD hospitalized patients and 150 healthy individuals were recruited. Serum 8-OHdG was measured by ELISA and the length of hospital stay was calculated. The number of acute exacerbations of COPD was tracked within 1 year after this hospitalization. Results The levels of serum 8-OHdG were elevated in COPD patients compared with the control group. Serum 8-OHdG was gradually elevated with decreased pulmonary function in COPD patients. Furthermore, Pearson linear association found that the levels of serum 8-OHdG were inversely correlated with pulmonary function and positively correlated with inflammatory cytokines in COPD patients. In addition, logistic regression analysis revealed that serum 8-OHdG elevation was a risk factor for pulmonary function decline in COPD patients. The length of hospital stay was tracked at this time. Higher serum 8-OHdG on admission increased the length of hospital stay among COPD patients. Conclusion Serum 8-OHdG on admission is positively correlated with the severity and adverse prognosis among COPD patients, suggesting that 8-OHdG may be involved in the pathogenesis of COPD. Serum 8-OHdG may be a biomarker to predict the progression of COPD.