Atrial fibrillation incidence, prevalence, predictors, and adverse outcomes in acute coronary syndromes: A pooled analysis of data from 8 million patients

Objective To summarize data on the prevalence/incidence, risk factors and prognosis of atrial fibrillation (AF) in patients with acute coronary syndromes (ACS). Methods MEDLINE, Embase, and Web of Science were searched to identify all published studies providing relevant data through August 23, 2020...

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Bibliographic Details
Published in:Journal of cardiovascular electrophysiology 2022-03, Vol.33 (3), p.414-422
Main Authors: Noubiap, Jean Jacques, Agbaedeng, Thomas A., Nyaga, Ulrich F., Lau, Dennis H., Worthley, Matthew I., Nicholls, Stephen J., Sanders, Prashanthan
Format: Article
Language:English
Subjects:
acute coronary syndrome
Acute Coronary Syndrome - diagnosis
Acute Coronary Syndrome - epidemiology
Acute Coronary Syndrome - therapy
Acute coronary syndromes
atrial fibrillation
Atrial Fibrillation - diagnosis
Atrial Fibrillation - epidemiology
Atrial Fibrillation - therapy
Cardiac arrhythmia
Cerebral infarction
complication
Congestive heart failure
Fibrillation
Heart failure
Humans
Incidence
Mortality
myocardial infarction
Prevalence
Risk Factors
stroke
Stroke - epidemiology
Stroke Volume
Ventricle
Ventricular Function, Left
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Summary:Objective To summarize data on the prevalence/incidence, risk factors and prognosis of atrial fibrillation (AF) in patients with acute coronary syndromes (ACS). Methods MEDLINE, Embase, and Web of Science were searched to identify all published studies providing relevant data through August 23, 2020. Random‐effects meta‐analysis method was used to pool estimates. Results We included 109 studies reporting data from a pooled population of 8 239 364 patients. The prevalence rates were 5.8% for pre‐existing AF, 7.3% for newly diagnosed AF, and 11.3% for prevalent (total) AF, in patients with ACS. Predictors of newly diagnosed AF included age (per year increase) (adjusted odds ratio [aOR]: 1.05), C‐reactive protein (aOR: 1.49), left atrial (LA) diameter (aOR: 1.08), LA dilatation (aOR: 2.32), left ventricular ejection fraction
ISSN:1045-3873
1540-8167
DOI:10.1111/jce.15351