Comparison of functional lumen imaging probe and high-resolution manometry to assess response after peroral endoscopic myotomy

Outcomes after peroral endoscopic myotomy (POEM) are assessed clinically by the Eckardt score (ES) or objectively by high-resolution manometry (HRM) and functional lumen imaging probe (FLIP). This study compared HRM and FLIP to evaluate clinical response after POEM. This was a single tertiary center...

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Bibliographic Details
Published in:Gastrointestinal endoscopy 2022-05, Vol.95 (5), p.855-863
Main Authors: DeWitt, John M., Siwiec, Robert, Kessler, William R., Wo, John M., Stainko, Sarah, Picklesimer Doyle, MaKayla, Perkins, Anthony, Dickason, Destenee, Al-Haddad, Mohamad A.
Format: Article
Language:English
Subjects:
Adult
Aged
Esophageal Achalasia - surgery
Esophageal Sphincter, Lower - surgery
Female
Humans
Male
Manometry - methods
Middle Aged
Myotomy - methods
Natural Orifice Endoscopic Surgery
Retrospective Studies
Treatment Outcome
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Summary:Outcomes after peroral endoscopic myotomy (POEM) are assessed clinically by the Eckardt score (ES) or objectively by high-resolution manometry (HRM) and functional lumen imaging probe (FLIP). This study compared HRM and FLIP to evaluate clinical response after POEM. This was a single tertiary center retrospective study of consecutive patients who underwent POEM for treatment-naive achalasia and with ≥6 months of follow-up. Baseline and follow-up testing in all patients included ES, HRM, and FLIP of the esophagogastric junction (EGJ). A normal post-POEM (or normalized) EGJ distensibility index (EGJ-DI) >2.8 mm2/mm Hg, maximum EGJ diameter (MxEGJD) ≥14 mm, and integrated relaxation pressure (IRP) 
ISSN:0016-5107
1097-6779
DOI:10.1016/j.gie.2021.12.029