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How do presentation age and CSF opening pressure level affect long-term prognosis of pseudotumor cerebri syndrome in children? Experience of a single tertiary clinic

Background Diagnosis and treatment of pseudotumor cerebri syndrome in children is still a challenge for clinicians. The aim of this study is to reveal the influence of presentation age and CSF opening pressure on long-term prognosis of pseudotumor cerebri and share our clinical data of the very youn...

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Published in:Child's nervous system 2022, Vol.38 (1), p.95-102
Main Authors: Ozturk, Gulten, Turkdogan, Dilşad, Unver, Olcay, Dericioglu, Volkan, Aslan, Bulent, Dagcinar, Adnan
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container_title Child's nervous system
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creator Ozturk, Gulten
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description Background Diagnosis and treatment of pseudotumor cerebri syndrome in children is still a challenge for clinicians. The aim of this study is to reveal the influence of presentation age and CSF opening pressure on long-term prognosis of pseudotumor cerebri and share our clinical data of the very young age (≤ 5-year) group. Method This retrospective study includes the patients followed by the Marmara University Pediatric Neurology Clinic between years 2012 and 2020 diagnosed with definite, probable, or suggestive pseudotumor cerebri syndrome according to modified Friedman criteria. Patients were classified into three groups according to presentation age: group 1: ≤ 5 years old; group 2: 6–10 years; and group 3 > 10 years old. CSF opening pressure was also categorized into three groups as CSF  30 cmH20. Results One hundred three patients, 62.1% female ( n  = 64), were enrolled in the study. Group 1 consisted of 16 patients (60% male), group 2 consisted of 30 patients (63.3% female), and group 3 consisted of 57 patients (66.7% female). The mean CSF opening pressure did not differ between the three age groups in our study ( p  > 0.05). Treatment response was not correlated with CSF opening pressure. Papilledema presence and level of CSF opening pressure were independent of age ( p  > 0.05). Conclusions Age at presentation and CSF opening pressure at diagnosis are not any predictive factors that influence long-term prognosis of pseudotumor cerebri syndrome in children. Evaluation and follow-up of children should be done in personalized approach.
doi_str_mv 10.1007/s00381-021-05365-8
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Experience of a single tertiary clinic</title><source>Springer Nature</source><creator>Ozturk, Gulten ; Turkdogan, Dilşad ; Unver, Olcay ; Dericioglu, Volkan ; Aslan, Bulent ; Dagcinar, Adnan</creator><creatorcontrib>Ozturk, Gulten ; Turkdogan, Dilşad ; Unver, Olcay ; Dericioglu, Volkan ; Aslan, Bulent ; Dagcinar, Adnan</creatorcontrib><description>Background Diagnosis and treatment of pseudotumor cerebri syndrome in children is still a challenge for clinicians. The aim of this study is to reveal the influence of presentation age and CSF opening pressure on long-term prognosis of pseudotumor cerebri and share our clinical data of the very young age (≤ 5-year) group. Method This retrospective study includes the patients followed by the Marmara University Pediatric Neurology Clinic between years 2012 and 2020 diagnosed with definite, probable, or suggestive pseudotumor cerebri syndrome according to modified Friedman criteria. Patients were classified into three groups according to presentation age: group 1: ≤ 5 years old; group 2: 6–10 years; and group 3 &gt; 10 years old. CSF opening pressure was also categorized into three groups as CSF &lt; 20 cmH20; CSF 20–30 cmH20; and CSF &gt; 30 cmH20. Results One hundred three patients, 62.1% female ( n  = 64), were enrolled in the study. Group 1 consisted of 16 patients (60% male), group 2 consisted of 30 patients (63.3% female), and group 3 consisted of 57 patients (66.7% female). The mean CSF opening pressure did not differ between the three age groups in our study ( p  &gt; 0.05). Treatment response was not correlated with CSF opening pressure. Papilledema presence and level of CSF opening pressure were independent of age ( p  &gt; 0.05). Conclusions Age at presentation and CSF opening pressure at diagnosis are not any predictive factors that influence long-term prognosis of pseudotumor cerebri syndrome in children. Evaluation and follow-up of children should be done in personalized approach.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-021-05365-8</identifier><identifier>PMID: 34568960</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cerebrospinal Fluid Pressure - physiology ; Child ; Child, Preschool ; Female ; Humans ; Male ; Medicine ; Medicine &amp; Public Health ; Neurosciences ; Neurosurgery ; Original Article ; Papilledema - diagnosis ; Prognosis ; Pseudotumor Cerebri - drug therapy ; Pseudotumor Cerebri - therapy ; Retrospective Studies</subject><ispartof>Child's nervous system, 2022, Vol.38 (1), p.95-102</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. 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Experience of a single tertiary clinic</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><addtitle>Childs Nerv Syst</addtitle><description>Background Diagnosis and treatment of pseudotumor cerebri syndrome in children is still a challenge for clinicians. The aim of this study is to reveal the influence of presentation age and CSF opening pressure on long-term prognosis of pseudotumor cerebri and share our clinical data of the very young age (≤ 5-year) group. Method This retrospective study includes the patients followed by the Marmara University Pediatric Neurology Clinic between years 2012 and 2020 diagnosed with definite, probable, or suggestive pseudotumor cerebri syndrome according to modified Friedman criteria. Patients were classified into three groups according to presentation age: group 1: ≤ 5 years old; group 2: 6–10 years; and group 3 &gt; 10 years old. CSF opening pressure was also categorized into three groups as CSF &lt; 20 cmH20; CSF 20–30 cmH20; and CSF &gt; 30 cmH20. Results One hundred three patients, 62.1% female ( n  = 64), were enrolled in the study. Group 1 consisted of 16 patients (60% male), group 2 consisted of 30 patients (63.3% female), and group 3 consisted of 57 patients (66.7% female). The mean CSF opening pressure did not differ between the three age groups in our study ( p  &gt; 0.05). Treatment response was not correlated with CSF opening pressure. Papilledema presence and level of CSF opening pressure were independent of age ( p  &gt; 0.05). Conclusions Age at presentation and CSF opening pressure at diagnosis are not any predictive factors that influence long-term prognosis of pseudotumor cerebri syndrome in children. Evaluation and follow-up of children should be done in personalized approach.</description><subject>Cerebrospinal Fluid Pressure - physiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Papilledema - diagnosis</subject><subject>Prognosis</subject><subject>Pseudotumor Cerebri - drug therapy</subject><subject>Pseudotumor Cerebri - therapy</subject><subject>Retrospective Studies</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1TAQhS0EopfCC7BAs2QT8E_s-K4QumopUqUu2q4txxkHV4kd7AToA_GeuL2FJQtrFvOd45k5hLxl9AOjtPtYKBWaNZTXJ4WSjX5GdqwVoqFC0udkR7lUTUdbekJelXJHKZOa71-SE9FKpfeK7sjvi_QThgRLxoJxtWtIEeyIYOMAh-tzSAvGEMdHoGwZYcIfOIH1Ht0KU4pjs2Keaz-NMZVQIHlYCm5DWrc5ZXCYsc8Byn0ccpoRQgT3LUxDxvgJzn4tmANGhw86C6X-NSFUyzXYfA9uCjG41-SFt1PBN0_1lNyen90cLprLqy9fD58vGyfabm1613tLB95LROd457u9GnTXMobSca1s22vLhNXS9p6xznPFhGey1VZz3aM4Je-PvnWb7xuW1cyhOJwmGzFtxVReKSrqHSvKj6jLqZSM3iw5zHVkw6h5iMcc4zE1HvMYj9FV9O7Jf-tnHP5J_uZRAXEESm3FEbO5S1uOdef_2f4BLgSe0w</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Ozturk, Gulten</creator><creator>Turkdogan, Dilşad</creator><creator>Unver, Olcay</creator><creator>Dericioglu, Volkan</creator><creator>Aslan, Bulent</creator><creator>Dagcinar, Adnan</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3800-693X</orcidid></search><sort><creationdate>2022</creationdate><title>How do presentation age and CSF opening pressure level affect long-term prognosis of pseudotumor cerebri syndrome in children? 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Experience of a single tertiary clinic</atitle><jtitle>Child's nervous system</jtitle><stitle>Childs Nerv Syst</stitle><addtitle>Childs Nerv Syst</addtitle><date>2022</date><risdate>2022</risdate><volume>38</volume><issue>1</issue><spage>95</spage><epage>102</epage><pages>95-102</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>Background Diagnosis and treatment of pseudotumor cerebri syndrome in children is still a challenge for clinicians. The aim of this study is to reveal the influence of presentation age and CSF opening pressure on long-term prognosis of pseudotumor cerebri and share our clinical data of the very young age (≤ 5-year) group. Method This retrospective study includes the patients followed by the Marmara University Pediatric Neurology Clinic between years 2012 and 2020 diagnosed with definite, probable, or suggestive pseudotumor cerebri syndrome according to modified Friedman criteria. Patients were classified into three groups according to presentation age: group 1: ≤ 5 years old; group 2: 6–10 years; and group 3 &gt; 10 years old. CSF opening pressure was also categorized into three groups as CSF &lt; 20 cmH20; CSF 20–30 cmH20; and CSF &gt; 30 cmH20. Results One hundred three patients, 62.1% female ( n  = 64), were enrolled in the study. Group 1 consisted of 16 patients (60% male), group 2 consisted of 30 patients (63.3% female), and group 3 consisted of 57 patients (66.7% female). The mean CSF opening pressure did not differ between the three age groups in our study ( p  &gt; 0.05). Treatment response was not correlated with CSF opening pressure. Papilledema presence and level of CSF opening pressure were independent of age ( p  &gt; 0.05). Conclusions Age at presentation and CSF opening pressure at diagnosis are not any predictive factors that influence long-term prognosis of pseudotumor cerebri syndrome in children. 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subjects Cerebrospinal Fluid Pressure - physiology
Child
Child, Preschool
Female
Humans
Male
Medicine
Medicine & Public Health
Neurosciences
Neurosurgery
Original Article
Papilledema - diagnosis
Prognosis
Pseudotumor Cerebri - drug therapy
Pseudotumor Cerebri - therapy
Retrospective Studies
title How do presentation age and CSF opening pressure level affect long-term prognosis of pseudotumor cerebri syndrome in children? Experience of a single tertiary clinic
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