Chirality Inversion in Self‐Assembled Nanocomposites Directed by Curvature‐Mediated Interactions

Nanoscale curvature‐dependent interactions are of paramount importance in biological systems. Here, we report that nanoscale curvature plays an important role in regulating the chirality of self‐assembled nanocomposites from chiral organic molecules and achiral nanoparticles. Specifically, we show t...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2022-03, Vol.61 (10), p.e202117406-n/a
Main Authors: Gong, Yanjun, Cao, Zhaozhen, Zhang, Zongze, Liu, Rongjuan, Zhang, Fenghua, Wei, Jingjing, Yang, Zhijie
Format: Article
Language:English
Subjects:
Chirality
Curvature
Molecular dynamics
Nanocomposites
Nanoparticles
Nanoscale Curvature
Nanotubes
Nucleation
Oligomerization
Organic chemistry
Supramolecular Chirality
Van Der Waals Forces
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Summary:Nanoscale curvature‐dependent interactions are of paramount importance in biological systems. Here, we report that nanoscale curvature plays an important role in regulating the chirality of self‐assembled nanocomposites from chiral organic molecules and achiral nanoparticles. Specifically, we show that the supramolecular chirality of the nanocomposites markedly depends on the nanoparticle curvature, where small‐sized nanoparticles of high curvature and large‐sized nanoparticles of low curvature lead to nanocomposites with opposite chirality. Quantitative kinetic experiments and molecular dynamics simulations reveal that nanoparticle curvature plays a key role in promoting the pre‐nucleation oligomerization of chiral molecules, which consequently regulates the supramolecular chirality of the nanocomposites. We anticipate that this study will aid in rational design of an artificial cooperative system giving rise to emergent assembling phenomena that can be surprisingly rich and often cannot be understood by studying the conventional noncooperative systems. An active role of achiral nanoparticles in regulating supramolecular chirality of the nanocomposites is reported. Nanoparticle‐curvature‐dependent supramolecular chirality in nanotubular composites was discovered, where small‐sized nanoparticles of high curvature and large‐sized nanoparticles of low curvature lead to nanotubular composites with opposite chirality.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202117406