Ultrasensitive Detection of Aqueous Uranyl Based on Uranyl‐Triggered Protein Photocleavage

The detection of environmental uranyl is attracting increasing attention. However, the available detection strategies mainly depend on the selective recognition of uranyl, which is subject to severe interference by coexisting metal ions. Herein, based on the unique uranyl‐triggered photocleavage pro...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2022-03, Vol.61 (10), p.e202115886-n/a
Main Authors: Feng, Tiantian, Yuan, Yihui, Zhao, Shilei, Feng, Lijuan, Yan, Bingjie, Cao, Meng, Zhang, Jiacheng, Sun, Wenyan, Lin, Ke, Wang, Ning
Format: Article
Language:English
Subjects:
Attenuation
Emission
Emissions
Fluorescence
Metal ions
Photocleavage
Proteins
Selectivity
Sensitivity
Uranyl Detection
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Summary:The detection of environmental uranyl is attracting increasing attention. However, the available detection strategies mainly depend on the selective recognition of uranyl, which is subject to severe interference by coexisting metal ions. Herein, based on the unique uranyl‐triggered photocleavage property, the protein BSA is labelled with fluorescent molecules that exhibit an aggregation‐induced emission effect for uranyl detection. Uranyl‐triggered photocleavage causes the separation of the fluorescent‐molecule‐labelled protein fragments, leading to attenuation of the emission fluorescence, which is used as a signal for uranyl detection. This detection strategy shows high selectivity for uranyl and an ultralow detection limit of 24 pM with a broad detection range covering five orders of magnitude. The detection method also shows high reliability and stability, making it a promising technique for practical applications in diverse environments. A unique uranyl‐triggered photocleavage property is used for uranyl detection in diverse environments. This method is characterized by ultrasensitive detection, a wide detection range, as well as extensive environmental adaptability and is among the best‐performing uranyl detection methods.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202115886