Immunohistochemistry of the oncofetal protein IMP3 is helpful in the diagnosis of intravascular large B‐cell lymphoma using skin biopsy

Background The oncofetal protein insulin‐like growth factor 2 mRNA binding protein‐3 (IMP3) is expressed in various cancers. In this study, we examined the diagnostic utility of IMP3 immunohistochemistry in the context of intravascular large B‐cell lymphoma (IVL). Methods We obtained 25 skin biopsy...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2022-05, Vol.49 (5), p.438-441
Main Authors: Odani, Kentaro, Fujimoto, Masakazu, Hirata, Masahiro, Nishikori, Momoko, Usui, Shunya, Yamada, Yosuke, Saeki, Miho, Ono, Kazuo, Iwasa, Yoko, Haga, Hironori
Format: Article
Language:English
Subjects:
B-cell lymphoma
Beta cells
Biopsy
CD34 antigen
Immunohistochemistry
IMP3
Insulin
intravascular large B‐cell lymphoma
Lymphoma
mRNA
Pax5 protein
Proteins
skin biopsy
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Summary:Background The oncofetal protein insulin‐like growth factor 2 mRNA binding protein‐3 (IMP3) is expressed in various cancers. In this study, we examined the diagnostic utility of IMP3 immunohistochemistry in the context of intravascular large B‐cell lymphoma (IVL). Methods We obtained 25 skin biopsy (SB) specimens diagnosed as IVL and nine IVL‐negative SB specimens from 27 IVL patients. Additionally, 27 negative SB specimens from 26 non‐IVL patients were obtained from our pathology archives. We performed IMP3 immunohistochemistry on these 61 SB specimens, considering IMP3 expression in any mononuclear cell as positive. In selected cases, triple immunostaining for IMP3, PAX5, and CD34 was performed to analyze the origin and location of IMP3‐positive cells. Results IMP3 was expressed in most intravascular lymphoma cells in all the 25 SB specimens diagnosed as IVL. Furthermore, our evaluation revealed the presence of intravascular IMP3‐positive B‐cells in five of the nine negative SB specimens from IVL patients; however, this was not observed in the 27 SB specimens from non‐IVL patients. Conclusion IMP3 was expressed in most IVL cells, and IMP3 immunohistochemistry could serve as a sensitive diagnostic aid for detecting IVL cells in SB.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.14196