Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections

Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important effector immune defense molecules in multicellular organisms. AMPs exert their antimicrobial activities through several mechanisms; thus far, induction of drug resistance through AMPs has been regarded as unlike...

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Bibliographic Details
Published in:Medicinal research reviews 2022-07, Vol.42 (4), p.1377-1422
Main Authors: Zhu, Yiyun, Hao, Weijing, Wang, Xia, Ouyang, Jianhong, Deng, Xinyi, Yu, Haining, Wang, Yipeng
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Anti-Infective Agents - therapeutic use
Antibiotics
Antimicrobial agents
Antimicrobial Cationic Peptides - pharmacology
Antimicrobial Cationic Peptides - therapeutic use
antimicrobial mechanism
Antimicrobial Peptides
antimicrobial peptides (AMPs)
conventional antibiotics
drug‐resistance
Humans
Multidrug resistant organisms
Peptides
synergy
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Summary:Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important effector immune defense molecules in multicellular organisms. AMPs exert their antimicrobial activities through several mechanisms; thus far, induction of drug resistance through AMPs has been regarded as unlikely. Therefore, they have great potential as new generation antimicrobial agents. To date, more than 30 AMP‐related drugs are in the clinical trial phase. In recent years, studies show that some AMPs and conventional antibiotics have synergistic effects. The combined use of AMPs and antibiotics can kill drug‐resistant pathogens, prevent drug resistance, and significantly improve the therapeutic effects of antibiotics. In this review, we discuss the progress in synergistic studies on AMPs and conventional antibiotics. An overview of the current understanding of the functional scope of AMPs, ongoing clinical trials, and challenges in the development processes are also presented.
ISSN:0198-6325
1098-1128
DOI:10.1002/med.21879