Event‐recurring multiband SWIFT functional MRI with 200‐ms temporal resolution during deep brain stimulation and isoflurane‐induced burst suppression in rat

Purpose To develop a high temporal resolution functional MRI method for tracking repeating events in the brain. Methods We developed a novel functional MRI method using multiband sweep imaging with Fourier transformation (SWIFT), termed event‐recurring SWIFT (EVER‐SWIFT). The method is able to image...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2022-06, Vol.87 (6), p.2872-2884
Main Authors: Paasonen, Ekaterina, Paasonen, Jaakko, Lehto, Lauri J., Pirttimäki, Tiina, Laakso, Hanne, Wu, Lin, Ma, Jun, Idiyatullin, Djaudat, Tanila, Heikki, Mangia, Silvia, Michaeli, Shalom, Gröhn, Olli
Format: Article
Language:English
Subjects:
Activity patterns
Animals
Brain
Brain - diagnostic imaging
Brain - physiology
DBS
Deep Brain Stimulation
fast imaging
Firing pattern
fMRI
Fourier transforms
Functional magnetic resonance imaging
HRF
Isoflurane
Isoflurane - pharmacology
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
MB‐SWIFT
Medical imaging
MSN
Neuroimaging
Neuromodulation
Rats
Stimulation
Temporal resolution
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Summary:Purpose To develop a high temporal resolution functional MRI method for tracking repeating events in the brain. Methods We developed a novel functional MRI method using multiband sweep imaging with Fourier transformation (SWIFT), termed event‐recurring SWIFT (EVER‐SWIFT). The method is able to image similar repeating events with subsecond temporal resolution. Here, we demonstrate the use of EVER‐SWIFT for detecting functional MRI responses during deep brain stimulation of the medial septal nucleus and during spontaneous isoflurane‐induced burst suppression in the rat brain at 9.4 T with 200‐ms temporal resolution. Results The EVER‐SWIFT approach showed that the shapes and time‐to‐peak values of the response curves to deep brain stimulation significantly differed between downstream brain regions connected to the medial septal nucleus, resembling findings obtained with traditional 2‐second temporal resolution. In contrast, EVER‐SWIFT allowed for detailed temporal measurement of a spontaneous isoflurane‐induced bursting activity pattern, which was not achieved with traditional temporal resolution. Conclusion The EVER‐SWIFT technique enables subsecond 3D imaging of both stimulated and spontaneously recurring brain activities, and thus holds great potential for studying the mechanisms of neuromodulation and spontaneous brain activity.
ISSN:0740-3194
1522-2594
1522-2594
DOI:10.1002/mrm.29154