Predicting papillary thyroid carcinoma cervical lymph node metastases: an algorithm using the American College of Radiology Thyroid Imaging, Reporting and Data System

• Published in: Acta radiologica (1987) 2023-01, Vol.64 (1), p.101-107
• Main Authors: Shangguan, Ronger, Kan, Guangjuan, Yang, Jing, Bao, Lingyun
• Format: Article
• Language: English
• Subjects: Algorithms; Humans; Lymphatic Metastasis - diagnostic imaging; Radiology; Retrospective Studies; Thyroid Cancer, Papillary - diagnostic imaging; Thyroid Cancer, Papillary - secondary; Thyroid Neoplasms - pathology; Thyroid Nodule - pathology
• ISSN: 0284-1851; 1600-0455
• DOI: 10.1177/02841851211069779

Background It is important to predict lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) preoperatively; however, the relationship between the American College of Radiology Thyroid Imaging, Reporting and Data System (ACR TI-RADS) score and cervical LNM remains unclear. Purpose To evaluate the association between the ACR TI-RADS score and cervical LNM in patients with PTC. Material and Methods This retrospective study consisted of 474 patients with 548 PTCs. Cervical LNM including central LNM (CLNM) and lateral LNM (LLNM) were confirmed by pathology. Univariate and multivariate analyses were performed to investigate the risk factors of CLNM and LLNM. Results Multivariate logistic regression analyses indicated that younger age and multifocality were risk factors for CLNM in PTCs with TR5. In addition, younger age, larger tumor size, and Hashimoto’s thyroiditis (HT) were risk factors for LLNM in PTCs ≥ 10 mm with TR5. In PTCs with TR4, ACR TI-RADS scores 5–6 conferred risks for LNM. In PTCs ≥ 10 mm with TR5, ACR TI-RADS scores ≥9 were risk factors for LLNM. Conclusion A higher ACR TI-RADS score is a predictor for cervical LNM in PTCs with TR4 and PTCs ≥ 10 mm with TR5.