Specific Neuropeptide Expression in Crohn’s Disease Ileocolonic Resection Specimens Is Not Associated with Plexitis at the Ileal Margin or Postoperative Recurrence

Background Myenteric plexitis is considered a risk factor for postoperative recurrence (POR) in Crohn’s disease (CD). The primary purpose of this study was to evaluate the association between neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), and substance P (SP) expression and plexitis at t...

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Bibliographic Details
Published in:Journal of gastrointestinal surgery 2022-04, Vol.26 (4), p.887-899
Main Authors: Gklavas, Antonios, Tiniakos, Dina, Karandrea, Despoina, Karamanolis, George, Bamias, Giorgos, Papaconstantinou, Ioannis
Format: Article
Language:English
Subjects:
Crohn Disease - complications
Crohn Disease - surgery
Crohn's disease
Endoscopy
Gastroenterology
Gastrointestinal surgery
Granulomas
Hospitals
Humans
Ileum - surgery
Inflammatory bowel disease
Lymphocytes
Margins of Excision
Medicine
Medicine & Public Health
Neoplasm Recurrence, Local - complications
Neuropeptides
Original Article
Patients
Peptides
Postoperative period
Prognosis
Recurrence
Retrospective Studies
Risk factors
Surgery
Tumor necrosis factor-TNF
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Summary:Background Myenteric plexitis is considered a risk factor for postoperative recurrence (POR) in Crohn’s disease (CD). The primary purpose of this study was to evaluate the association between neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), and substance P (SP) expression and plexitis at the proximal resection margin. The secondary aim was to identify risk factors for POR. Methods A retrospective, single-center study on CD patients who underwent ileocolonic resection (ICR) between January 2010 and December 2016 was conducted. The presence and severity of plexitis were evaluated by hematoxylin and eosin stain. Mast cells were highlighted by Giemsa stain. Immunohistochemistry was used to identify T lymphocytes and NPY-, VIP-, and SP-ergic neurons. Neuropeptide expression was quantified using image analysis. Results Seventy-nine patients were included. No association was detected between NPY, VIP, and SP expression and plexitis. Similarly, the number of involved inflammatory cells, T lymphocytes or mast cells was not correlated with neuropeptide expression. Smoking (hazard ratio [HR] 4.07; 95% confidence interval [CI] 2.08–7.94; p  
ISSN:1091-255X
1873-4626
DOI:10.1007/s11605-021-05215-7