Blockade of α2-Adrenergic Receptors Inhibits Functional Parameters of Langendorff-Isolated Rat Heart

We studied the effect of α2-adrenoreceptor antagonist yohimbine in concentrations of 10 —9 -10 —6 M on the inotropy, chronotropy, and coronary flow of the Langendorff-isolated rat heart. It was found that antagonist of α2-adrenoreceptors yohimbine changes all the studied parameters of the isolated h...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2022, Vol.172 (3), p.288-291
Main Authors: Khisamieva, L. I., Chershintseva, N. N., Kuptsova, A. M., Ziyatdinova, N. I., Zefirov, T. L.
Format: Article
Language:English
Subjects:
Adrenergic receptors
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Heart
Heart Rate
Hibernation
Internal Medicine
Laboratory Medicine
Muscle contraction
Myocardial Contraction
Myocardium
Pathology
Rats
Receptors, Adrenergic
Signal Transduction
Ventricle
Yohimbine
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Summary:We studied the effect of α2-adrenoreceptor antagonist yohimbine in concentrations of 10 —9 -10 —6 M on the inotropy, chronotropy, and coronary flow of the Langendorff-isolated rat heart. It was found that antagonist of α2-adrenoreceptors yohimbine changes all the studied parameters of the isolated heart. The force of left ventricular myocardial contraction, HR, and coronary flow decreased after application of all concentrations of α2-adrenoreceptor antagonist. The maximum inotropic, chronotropic, and vascular effects were observed when the antagonist was applied to the perfused solution in a concentration of 10 —9 M. The minimum decrease in coronary flow and HR was observed when yohimbine was applied in a concentration of 10 —8 M; minimum effect on myocardial contractility was revealed at α2-adrenoreceptor blocker concentration of 10 —7 M.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-022-05378-6