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Neurosyphilis in the Northern Territory of Australia: a clinical guideline
Background The Northern Territory (NT) of Australia is currently experiencing a syphilis epidemic. Neurosyphilis is commonly considered in the differential diagnosis for patients presenting with neurologic conditions such as dementia and stroke in the NT. Aims To explore the local epidemiologic, dia...
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| Published in: | Internal medicine journal 2023-05, Vol.53 (5), p.738-744 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 744 |
| container_issue | 5 |
| container_start_page | 738 |
| container_title | Internal medicine journal |
| container_volume | 53 |
| creator | Birrell, Johanna Marie Lowe, Michael Gunathilake, Manoji Krause, Vicki Lynn |
| description | Background
The Northern Territory (NT) of Australia is currently experiencing a syphilis epidemic. Neurosyphilis is commonly considered in the differential diagnosis for patients presenting with neurologic conditions such as dementia and stroke in the NT.
Aims
To explore the local epidemiologic, diagnostic and treatment complexities of neurosyphilis in the NT and produce a guideline for clinical practice.
Methods
A database search was undertaken and local and global neurosyphilis guidelines were analysed. A guideline was created based on findings of the critical review and consultation with local multidisciplinary experts.
Results
Neurosyphilis is frequently encountered in the NT but studies suggest it is often undertreated. Dementia is the most common clinical presentation locally. Establishing a diagnosis of neurosyphilis is complex and requires stepwise evaluation of clinical, laboratory and radiological findings.
Conclusions
A clinical guideline and algorithm have been developed for the diagnosis and management of patients with neurosyphilis. |
| doi_str_mv | 10.1111/imj.15691 |
| format | article |
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The Northern Territory (NT) of Australia is currently experiencing a syphilis epidemic. Neurosyphilis is commonly considered in the differential diagnosis for patients presenting with neurologic conditions such as dementia and stroke in the NT.
Aims
To explore the local epidemiologic, diagnostic and treatment complexities of neurosyphilis in the NT and produce a guideline for clinical practice.
Methods
A database search was undertaken and local and global neurosyphilis guidelines were analysed. A guideline was created based on findings of the critical review and consultation with local multidisciplinary experts.
Results
Neurosyphilis is frequently encountered in the NT but studies suggest it is often undertreated. Dementia is the most common clinical presentation locally. Establishing a diagnosis of neurosyphilis is complex and requires stepwise evaluation of clinical, laboratory and radiological findings.
Conclusions
A clinical guideline and algorithm have been developed for the diagnosis and management of patients with neurosyphilis.</description><identifier>ISSN: 1444-0903</identifier><identifier>EISSN: 1445-5994</identifier><identifier>DOI: 10.1111/imj.15691</identifier><identifier>PMID: 35000259</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Dementia ; Dementia disorders ; Differential diagnosis ; Epidemiology ; Humans ; neurology ; Neurosyphilis ; Neurosyphilis - diagnosis ; Northern Territory ; Patients ; Syphilis ; Syphilis - diagnosis ; Syphilis Serodiagnosis</subject><ispartof>Internal medicine journal, 2023-05, Vol.53 (5), p.738-744</ispartof><rights>2022 Royal Australasian College of Physicians.</rights><rights>2023 Royal Australasian College of Physicians</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-683ff0cf8c5222b47a2444c8877bab5f98e7c7f79299380bcdbe16883179c8653</citedby><cites>FETCH-LOGICAL-c3531-683ff0cf8c5222b47a2444c8877bab5f98e7c7f79299380bcdbe16883179c8653</cites><orcidid>0000-0002-5142-313X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27900,27901</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35000259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Birrell, Johanna Marie</creatorcontrib><creatorcontrib>Lowe, Michael</creatorcontrib><creatorcontrib>Gunathilake, Manoji</creatorcontrib><creatorcontrib>Krause, Vicki Lynn</creatorcontrib><title>Neurosyphilis in the Northern Territory of Australia: a clinical guideline</title><title>Internal medicine journal</title><addtitle>Intern Med J</addtitle><description>Background
The Northern Territory (NT) of Australia is currently experiencing a syphilis epidemic. Neurosyphilis is commonly considered in the differential diagnosis for patients presenting with neurologic conditions such as dementia and stroke in the NT.
Aims
To explore the local epidemiologic, diagnostic and treatment complexities of neurosyphilis in the NT and produce a guideline for clinical practice.
Methods
A database search was undertaken and local and global neurosyphilis guidelines were analysed. A guideline was created based on findings of the critical review and consultation with local multidisciplinary experts.
Results
Neurosyphilis is frequently encountered in the NT but studies suggest it is often undertreated. Dementia is the most common clinical presentation locally. Establishing a diagnosis of neurosyphilis is complex and requires stepwise evaluation of clinical, laboratory and radiological findings.
Conclusions
A clinical guideline and algorithm have been developed for the diagnosis and management of patients with neurosyphilis.</description><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Differential diagnosis</subject><subject>Epidemiology</subject><subject>Humans</subject><subject>neurology</subject><subject>Neurosyphilis</subject><subject>Neurosyphilis - diagnosis</subject><subject>Northern Territory</subject><subject>Patients</subject><subject>Syphilis</subject><subject>Syphilis - diagnosis</subject><subject>Syphilis Serodiagnosis</subject><issn>1444-0903</issn><issn>1445-5994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKAzEUQIMotlYX_oAE3Ohi2jwmk8RdKT4qtW7qOmTSjE2ZR006SP_e2KkuBEPgJnA4XA4AlxgNcTwjV62HmGUSH4E-TlOWMCnT4_07TZBEtAfOQlgjhDmV6SnoUYYQIkz2wfPctr4Ju83KlS5AV8PtysJ54-PwNVxY79228TvYFHDchq3XpdN3UENTutoZXcL31i1t_NhzcFLoMtiLwxyAt4f7xeQpmb0-TifjWWIoozjJBC0KZAphGCEkT7kmcU0jBOe5zlkhheWGF1wSKalAuVnmFmdCUMylERmjA3DTeTe--Wht2KrKBWPLUte2aYMiGRYsXkoiev0HXTetr-N2iojoo0wQHqnbjjKxRPC2UBvvKu13CiP1HVjFwGofOLJXB2ObV3b5S_4UjcCoAz5daXf_m9T05blTfgGz34Me</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Birrell, Johanna Marie</creator><creator>Lowe, Michael</creator><creator>Gunathilake, Manoji</creator><creator>Krause, Vicki Lynn</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5142-313X</orcidid></search><sort><creationdate>202305</creationdate><title>Neurosyphilis in the Northern Territory of Australia: a clinical guideline</title><author>Birrell, Johanna Marie ; Lowe, Michael ; Gunathilake, Manoji ; Krause, Vicki Lynn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-683ff0cf8c5222b47a2444c8877bab5f98e7c7f79299380bcdbe16883179c8653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Differential diagnosis</topic><topic>Epidemiology</topic><topic>Humans</topic><topic>neurology</topic><topic>Neurosyphilis</topic><topic>Neurosyphilis - diagnosis</topic><topic>Northern Territory</topic><topic>Patients</topic><topic>Syphilis</topic><topic>Syphilis - diagnosis</topic><topic>Syphilis Serodiagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Birrell, Johanna Marie</creatorcontrib><creatorcontrib>Lowe, Michael</creatorcontrib><creatorcontrib>Gunathilake, Manoji</creatorcontrib><creatorcontrib>Krause, Vicki Lynn</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Internal medicine journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Birrell, Johanna Marie</au><au>Lowe, Michael</au><au>Gunathilake, Manoji</au><au>Krause, Vicki Lynn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurosyphilis in the Northern Territory of Australia: a clinical guideline</atitle><jtitle>Internal medicine journal</jtitle><addtitle>Intern Med J</addtitle><date>2023-05</date><risdate>2023</risdate><volume>53</volume><issue>5</issue><spage>738</spage><epage>744</epage><pages>738-744</pages><issn>1444-0903</issn><eissn>1445-5994</eissn><abstract>Background
The Northern Territory (NT) of Australia is currently experiencing a syphilis epidemic. Neurosyphilis is commonly considered in the differential diagnosis for patients presenting with neurologic conditions such as dementia and stroke in the NT.
Aims
To explore the local epidemiologic, diagnostic and treatment complexities of neurosyphilis in the NT and produce a guideline for clinical practice.
Methods
A database search was undertaken and local and global neurosyphilis guidelines were analysed. A guideline was created based on findings of the critical review and consultation with local multidisciplinary experts.
Results
Neurosyphilis is frequently encountered in the NT but studies suggest it is often undertreated. Dementia is the most common clinical presentation locally. Establishing a diagnosis of neurosyphilis is complex and requires stepwise evaluation of clinical, laboratory and radiological findings.
Conclusions
A clinical guideline and algorithm have been developed for the diagnosis and management of patients with neurosyphilis.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>35000259</pmid><doi>10.1111/imj.15691</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5142-313X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1444-0903 |
| ispartof | Internal medicine journal, 2023-05, Vol.53 (5), p.738-744 |
| issn | 1444-0903 1445-5994 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2618518532 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Dementia Dementia disorders Differential diagnosis Epidemiology Humans neurology Neurosyphilis Neurosyphilis - diagnosis Northern Territory Patients Syphilis Syphilis - diagnosis Syphilis Serodiagnosis |
| title | Neurosyphilis in the Northern Territory of Australia: a clinical guideline |
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