Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice

• Published in: Neurotoxicology (Park Forest South) 2022-03, Vol.89, p.55-66
• Main Authors: Saveleva, Liudmila, Vartiainen, Petra, Górová, Veronika, Chew, Sweelin, Belaya, Irina, Konttinen, Henna, Zucchelli, Martina, Korhonen, Paula, Kaartinen, Emma, Kortelainen, Miika, Lamberg, Heikki, Sippula, Olli, Malm, Tarja, Jalava, Pasi I., Kanninen, Katja M.
• Format: Article
• Language: English
• Subjects: 5xFAD; Air Pollutants - toxicity; Air pollution; Alzheimer's disease; Amyloid beta-Peptides; Animals; Brain; Cytokines; Dementia disorders; Epidemiology; Exposure; Genotypes; Hippocampus; Inflammation; Inflammation - chemically induced; Inhalation; Inhalation Exposure - adverse effects; Inhalation Exposure - analysis; Interferon; Mice; Mitochondria; Neurodegeneration; Neurodegenerative diseases; Neuroinflammation; Neurotoxicology; Outdoor air quality; Oxidative stress; Particle Size; Particulate matter; Particulate Matter - toxicity; Pollutants; Respiration; Superoxide dismutase; Ultrafine particles (UFP); Ultrafines; γ-Interferon
• ISSN: 0161-813X; 1872-9711
• DOI: 10.1016/j.neuro.2022.01.001

[Display omitted] •Ultrafine particulate matter increases interferon gamma levels in mouse plasma.•Air pollution induces inflammatory cytokines in mouse hippocampi and olfactory bulbs.•Inhalation exposure up-regulates SOD2 in the hippocampi of 5xFAD but not WT mice. Epidemiological studies reveal that air pollution exposure may exacerbate neurodegeneration. Ultrafine particles (UFPs) are pollutants that remain unregulated in ambient air by environmental agencies. Due to their small size (