Viral shedding and the durability of immunoglobulin G antibodies to severe acute respiratory syndrome coronavirus 2

We followed 45 participants in Surabaya, Indonesia, for 10 months and compared their PCR and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) immunoglobulin G (IgG) results. As much as 13 out of 45 participants were IgG seropositive at least once while the remaining 32 stayed IgG seroneg...

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Bibliographic Details
Published in:Microbiology and immunology 2022-04, Vol.66 (4), p.173-178
Main Authors: Lusida, Maria Inge, Gunawan, Emily, Megasari, Ni Luh Ayu, Yamani, Laura Navika, Juniastuti, Utsumi, Takako, Mori, Yasuko
Format: Article
Language:English
Subjects:
Antibodies, Viral
Coronaviruses
COVID-19
Humans
Immunoglobulin G
Immunoglobulin M
Immunoglobulins
Indonesia
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Virus Shedding
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Summary:We followed 45 participants in Surabaya, Indonesia, for 10 months and compared their PCR and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) immunoglobulin G (IgG) results. As much as 13 out of 45 participants were IgG seropositive at least once while the remaining 32 stayed IgG seronegative throughout the study. Among 13 seropositive participants, 9 were consecutively seropositive at least twice and were eligible for IgG longevity evaluation. The duration of IgG detection varied from 47 to ≥233 days. We observed intermittent re‐positive PCR results suggestive of viral shedding in participants with a longer duration of IgG detection.
ISSN:0385-5600
1348-0421
DOI:10.1111/1348-0421.12962