Using In Vivo Assessment on Host Defense Peptide Mimicking Polymer-Modified Surfaces for Combating Implant Infections

Infections have accounted for the majority of failures in implants over the past decades. Host defense peptide mimicking polymers have been considered as one of the promising antimicrobial candidates for their cost-effective synthesis, broad-spectrum antimicrobial activity, low propensity to induce...

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Bibliographic Details
Published in:ACS applied bio materials 2021-05, Vol.4 (5), p.3811-3829
Main Authors: Qian, Yuxin, Deng, Shuai, Lu, Ziyi, She, Yunrui, Xie, Jiayang, Cong, Zihao, Zhang, Wenjing, Liu, Runhui
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antimicrobial Cationic Peptides - chemistry
Antimicrobial Cationic Peptides - pharmacology
Bacteria - drug effects
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Humans
Materials Testing
Microbial Sensitivity Tests
Particle Size
Polymers - chemistry
Polymers - pharmacology
Prostheses and Implants - microbiology
Prosthesis-Related Infections - drug therapy
Prosthesis-Related Infections - microbiology
Surface Properties
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Summary:Infections have accounted for the majority of failures in implants over the past decades. Host defense peptide mimicking polymers have been considered as one of the promising antimicrobial candidates for their cost-effective synthesis, broad-spectrum antimicrobial activity, low propensity to induce drug resistance, and remarkable biocompatibility. In this review, covalent-grafting strategies are mainly discussed to tether host defense peptide mimicking polymers on surfaces, aiming to obtain potent antimicrobial activity. In addition to the antimicrobial function, we review the antimicrobial mechanism of these polymer-modified antimicrobial surfaces in precedent literatures. We also review the in vivo subcutaneous implant infection models that are critical assessments for potential biomedical applications. In the end, we provide our perspective on the future development of this field, especially for biomedical applications.
ISSN:2576-6422
2576-6422
DOI:10.1021/acsabm.0c01066