Vascularization Approaches in Tissue Engineering: Recent Developments on Evaluation Tests and Modulation

This review focuses on vascularization and strategies involved in its evaluation and modulation. Clinical issues associated with engineered tissues of an atomically relevant size that require a vascular network to supply their cells with nutrients and oxygen are analyzed in terms of vascular network...

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Bibliographic Details
Published in:ACS applied bio materials 2021-04, Vol.4 (4), p.2941-2956
Main Authors: Lopes, Soraia V, Collins, Maurice N, Reis, Rui L, Oliveira, Joaquim M, Silva-Correia, Joana
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Humans
Materials Testing
Neovascularization, Physiologic
Particle Size
Tissue Engineering
Tissue Scaffolds - chemistry
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Summary:This review focuses on vascularization and strategies involved in its evaluation and modulation. Clinical issues associated with engineered tissues of an atomically relevant size that require a vascular network to supply their cells with nutrients and oxygen are analyzed in terms of vascular network formation within scaffolds, which can be produced from varying biomaterials, with the capability of connecting to the vasculature of the patient. Developing angiogenesis techniques and monitoring of angiogenesis development as well as how these methods can be further utilized to tailor vascularization within large tissue engineered constructs are also discussed. Finally, we offer a glimpse toward the future by providing an outlook for vascularization and associated emerging bioprinting concepts in tissue engineering applications.
ISSN:2576-6422
2576-6422
DOI:10.1021/acsabm.1c00051