Surface PEGylation via Ultrasonic Spray Deposition for the Biofouling Mitigation of Biomedical Interfaces

Air plasma and spray technology are common methods for surface modification. In this study, air plasma is used to generate hydroxyl groups on various material surfaces. Then random copolymers of styrene and ethylene glycol methacrylate (PS-r-PEGMA) are spray-coated to achieve coating densities rangi...

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Bibliographic Details
Published in:ACS applied bio materials 2022-01, Vol.5 (1), p.225-234
Main Authors: Tang, Shuo-Hsi, Venault, Antoine, Chou, Li-Hui, Lan, Ding-Hung, Dizon, Gian Vincent, Hsieh, Chun, Yeh, Chih-Chen, Liu, Cheng-Liang, Chang, Yung
Format: Article
Language:English
Subjects:
Biofouling - prevention & control
Polymers
Polystyrenes
Titanium
Ultrasonics
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Summary:Air plasma and spray technology are common methods for surface modification. In this study, air plasma is used to generate hydroxyl groups on various material surfaces. Then random copolymers of styrene and ethylene glycol methacrylate (PS-r-PEGMA) are spray-coated to achieve coating densities ranging between 0.1 and 0.6 mg/cm2. PS50-r-PEGMA50 led to the best overall antifouling properties, while a coating density of 0.3 mg/cm2 was enough to significantly reduce biofouling. This surface modification technique enabled efficient modification of a wide range of materials and biofouling reduction by at least 75% on polymeric surfaces (polystyrene, polyvinylidene fluoride, poly­(tetra­fluoroethylene), polydimethyl­siloxane), metallic surfaces (steel, titanium alloy), or ceramic surface (glass). Applied to the modification of well plate used for blood-typing, this antifouling modification permitted to greatly increase the signal sensitivity (×4).
ISSN:2576-6422
2576-6422
DOI:10.1021/acsabm.1c01053