Mechano-Responsive Piezoelectric Nanofiber as an On-Demand Drug Delivery Vehicle

The control over biodistribution and pharmacokinetics is critical to enhance the efficacy and minimize the side effects of therapeutic agents. To address the need for an on-demand drug delivery system for precise control over the release time and the quantity of drugs, we exploited the mechano-respo...

Full description

Saved in:
Bibliographic Details
Published in:ACS applied bio materials 2021-04, Vol.4 (4), p.3706-3715
Main Authors: Jariwala, Tanvi, Ico, Gerardo, Tai, Youyi, Park, Honghyun, Myung, Nosang V, Nam, Jin
Format: Article
Language:English
Subjects:
Animals
Drug Carriers - chemistry
Drug Liberation
Gentian Violet - chemistry
Gentian Violet - metabolism
Microwaves
Nanofibers - chemistry
Polyvinyls - chemistry
Skin - chemistry
Skin - metabolism
Static Electricity
Surface Properties
Swine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The control over biodistribution and pharmacokinetics is critical to enhance the efficacy and minimize the side effects of therapeutic agents. To address the need for an on-demand drug delivery system for precise control over the release time and the quantity of drugs, we exploited the mechano-responsiveness of piezoelectric poly­(vinylidene fluoride-trifluroethylene) (P­(VDF-TrFE)) nanofibers for drug delivery applications. The large surface area-to-volume ratio inherent to nanomaterials, together with the transformative piezoelectric properties, allowed us to use the material as an ultrasensitive and mechano-responsive drug delivery platform driven by the direct piezoelectric effect. The intrinsic negative zeta potential of the nanofibers was utilized to electrostatically load cationic drug molecules, where surface potential changes by exogenous mechanical actuation trigger the release of drug molecules. We show that the drug release kinetics of the P­(VDF-TrFE) nanofibers depends on the fiber diameter, thus piezoelectric properties. We further demonstrated that the drug release quantity can be tuned by the applied pressure or dose of physiologically safe corporeal shockwaves as a mechanical stimulus in in vitro and ex vivo models. Overall, we demonstrated the utility of piezoelectric electrospun nanofibers for mechano-responsive controlled drug release.
ISSN:2576-6422
2576-6422
DOI:10.1021/acsabm.1c00232